Name: MU262
Brand: TargetMol
SKU: T212835
Rating: 4.5 (1 reviews)

生物活性

产品描述	MU262 is a structurally novel polycyclic heterocyclic small-molecule compound and a MUS81 inhibitor with an IC₅₀ value of 0.87 μM, which directly inhibits MUS81 catalytic activity through non-interfering DNA binding, inducing genomic instability in tumor cells and specifically inhibiting the HR/BIR repair pathways. MU262 can serve as a chemical biology tool for studying MUS81 function and as a lead compound for developing anticancer therapies that exploit DNA repair defects in cancer cells.
靶点活性	MUS81:0.87 μM
体外活性	方法：U2OS细胞加入 MU262 (0.5–1 μM)，处理 10 天，10天后结晶紫染色，分光光度定量评估细胞克隆能力。结果：MU262 显著降低细胞克隆形成能力。[1]

化学信息

分子量	374.38
分子式	C₂₀H₁₅FN₆O
CAS No.	1846587-13-0
Smiles	FC1=CC=C(C=C1)C2=C3N=NC(C4=NC=5C=CC=CC5N4)=C(O)N3N=C2CC
密度	no data available

储存&溶解度

存储	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. 实际储存温度请以COA为准

MU262