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Anti-TIE1 Antibody (6Y648)
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产品编号 TMAY-00919
别名 tyrosine kinase with immunoglobulin-like and EGF-like domains 1, TIE, JTK14
Anti-TIE1 Antibody (6Y648) 是一种 Mouse 抗体，靶向 TIE1。Anti-TIE1 Antibody (6Y648) 可用于 ELISA(Det),IHC-P。
Anti-TIE1 Antibody (6Y648)
331 Anti-TIE1 Antibody (6Y648)
还可以产品编号 TMAY-00919 别名 tyrosine kinase with immunoglobulin-like and EGF-like domains 1, TIE, JTK14
Anti-TIE1 Antibody (6Y648) 是一种 Mouse 抗体，靶向 TIE1。Anti-TIE1 Antibody (6Y648) 可用于 ELISA(Det),IHC-P。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 20 μL | ¥ 580 | 5日内发货 | |
| 100 μL | ¥ 1,684 | 5日内发货 |
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-TIE1 Antibody (6Y648) is a Mouse antibody targeting TIE1. Anti-TIE1 Antibody (6Y648) can be used in ELISA(Det),IHC-P. |
| 别名 | tyrosine kinase with immunoglobulin-like and EGF-like domains 1, TIE, JTK14 |
| Ig Type | Mouse IgG2b |
| 克隆号 | 6Y648 |
| 交叉反应 | Human |
| 验证活性 | 1. Immunochemical staining of human TIE1 in human stomach carcinoma with mouse monoclonal antibody (1:60, formalin-fixed paraffin embedded sections). 2. Immunochemical staining of human TIE1 in human placenta with mouse monoclonal antibody (1:60, formalin-fixed paraffin embedded sections). 3. Immunochemical staining of human TIE1 in human liver(cirrhosis) with mouse monoclonal antibody (1:60, formalin-fixed paraffin embedded sections). |
| 应用 | ELISA(Det),IHC-P |
| 推荐剂量 | IHC-P: 1:50-1:200; ELISA(Det): 1:1000-1:10000 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human Tie1 (rh Tie1; TMPY-01910; NP_005415.1; Met 1-Gln 760). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | Tyrosine kinase with immunoglobulin-like and EGF-like domains 1 also known as Tie1 is an angiopoietin receptor and is an orphan receptor tyrosine kinase that is expressed almost exclusively in endothelial cells and that is required for normal embryonic vascular development. The receptor tyrosine kinase Tie1 is expressed primarily in vascular endothelial cells. The receptor has also been detected in epithelial tumours in breast, thyroid and gastric cancers and in tumour cell lines where it appears as a 45 kDa truncated receptor fragment. Tie1 promotes endothelial cell survival, but other studies have suggested that the Tie1 kinase has little to no activity. Embryos deficient in Tie1 failed to establish structural integrity of vascular endothelial cells, resulting in oedema and subsequently localized haemorrhage. Tie1 is significantly higher in human aortic endothelial cells than in human umbilical vein endothelial cells. Additionally, attachment of cells of monocytic lineage to endothelial cells is also enhanced by Tie1 expression. Collectively Tie1 has a proinflammatory property and may play a role in endothelial inflammatory diseases such as atherosclerosis. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Protein: Human Tie1 Protein (TMPY-01910) |
| 抗原种属 | Human |
| 研究领域 | Receptor Tyrosine Kinases (RTKs) |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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