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Anti-SSTR2 Antibody (1Z419)

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Anti-SSTR2 Antibody (1Z419)
产品编号 TMAH-01133
别名 somatostatin receptor 2

Anti-SSTR2 Antibody (1Z419) 是一种抗体,靶向 SSTR2。Anti-SSTR2 Antibody (1Z419) 可用于 ELISA, IHC。

Anti-SSTR2 Antibody (1Z419)

Anti-SSTR2 Antibody (1Z419)

Rating icon 还可以
Anti-SSTR2 Antibody (1Z419)
产品编号 TMAH-01133 别名 somatostatin receptor 2

Anti-SSTR2 Antibody (1Z419) 是一种抗体,靶向 SSTR2。Anti-SSTR2 Antibody (1Z419) 可用于 ELISA, IHC。

规格价格库存数量
50 μL
¥ 1,315
5日内发货
100 μL
¥ 2,180
5日内发货
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产品介绍

生物活性
产品描述
Anti-SSTR2 Antibody (1Z419) is an antibody targeting SSTR2. Anti-SSTR2 Antibody (1Z419) can be used in ELISA, IHC.
别名somatostatin receptor 2
Ig Type
Rabbit IgG
克隆号
1Z419
交叉反应
Human
验证活性
IHC image of TMAH-01133 diluted at 1:100 and staining in paraffin-embedded human pancreatic tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.
应用
推荐剂量
IHC:1:50-1:200.
抗体种类
Monoclonal
亚细胞定位Cell membrane; Multi-pass membrane protein. Cytoplasm. Note=Located mainly at the cell surface under basal conditions. Agonist stimulation results in internalization to the cytoplasm.
构建方式Recombinant Antibody
纯化方式Affinity-chromatography
性状Liquid
缓冲液Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
研究背景Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B. Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regulation of insulin receptor signaling through PTPN6. Inactivates SSTR3 receptor function following heterodimerization.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
A synthetic peptide: Human Somatostatin Receptor 2
抗原种属
Human
基因ID
Uniprot ID
研究领域
Neuroscience, Cancer, Metabolism
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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