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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-RIPK3 Antibody (8T623)

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货号 TMAB-12267

Anti-RIPK3 Antibody (8T623) 是一种 Mouse 抗体，靶向 RIPK3。Anti-RIPK3 Antibody (8T623) 可用于 WB。

Anti-RIPK3 Antibody (8T623)

Anti-RIPK3 Antibody (8T623)

一键复制产品信息
Rating icon 还可以
货号 TMAB-12267

Anti-RIPK3 Antibody (8T623) 是一种 Mouse 抗体，靶向 RIPK3。Anti-RIPK3 Antibody (8T623) 可用于 WB。

规格价格库存数量
50 μL
¥ 1,175
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100 μL
¥ 1,975
5日内发货
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产品介绍

生物活性
产品描述
Anti-RIPK3 Antibody (8T623) is a Mouse antibody targeting RIPK3. Anti-RIPK3 Antibody (8T623) can be used in WB.
Ig Type
IgG1, k
克隆号
8T623
反应种属
Human
应用WB
推荐剂量
WB: 1:500-1000
抗体种类
Monoclonal
宿主来源Mouse
亚细胞定位Cytoplasm. Cell membrane. Mitochondrion (Potential).
组织特异性Highly expressed in the pancreas. Detected at lower levels in heart, placenta, lung and kidney. Isoform 3 is significantly increased in colon and lung cancers.
构建方式Hybridoma Monoclonal Antibody
纯化方式Protein G purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景The product of this gene is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, and contains a C-terminal domain unique from other RIP family members. The encoded protein is predominantly localized to the cytoplasm, and can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. It is a component of the tumor necrosis factor (TNF) receptor-I signaling complex, and can induce apoptosis and weakly activate the NF-kappaB transcription factor. [provided by RefSeq, Jul 2008]
抗原信息
免疫原
Recombinant Protein: human RIPK3
抗原种属
Human
基因名称
RIPK3
基因ID
11035
蛋白名称
Receptor-interacting serine/threonine-protein kinase 3
Uniprot ID
Q9Y572
功能
Essential for programmed necrosis in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production.
化学信息
分子量Theoretical: 57 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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