Anti-RhoA Antibody (5G87)

Name: Anti-RhoA Antibody (5G87)
Brand: TargetMol
SKU: TMAH-01043
Rating: 4.5 (1 reviews)

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产品编号 TMAH-01043

别名 RHOH12, RHO12, ras homolog family member A, ARHA, ARH12

Anti-RhoA Antibody (5G87) 是一种抗体，靶向 RhoA。Anti-RhoA Antibody (5G87) 可用于 ELISA, WB。

Anti-RhoA Antibody (5G87)

还可以

产品编号 TMAH-01043 别名 RHOH12, RHO12, ras homolog family member A, ARHA, ARH12

Anti-RhoA Antibody (5G87) 是一种抗体，靶向 RhoA。Anti-RhoA Antibody (5G87) 可用于 ELISA, WB。

规格	价格	库存	数量
50 μL	¥ 1,300	5日内发货
100 μL	¥ 2,195	5日内发货

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产品描述	Anti-RhoA Antibody (5G87) is an antibody targeting RhoA. Anti-RhoA Antibody (5G87) can be used in ELISA, WB.
别名	RHOH12, RHO12, ras homolog family member A, ARHA, ARH12
Ig Type	Rabbit IgG
克隆号	5G87
交叉反应	Human
验证活性	Western Blot -Positive WB detected in: SH-SY5Y whole cell lysate -All lanes: Rho antibody at 1:1500 -Secondary: Goat polyclonal to rabbit IgG at 1/50000 dilution -Predicted band size: 22 kDa -Observed band size: 22 kDa
应用	ELISA, WB
推荐剂量	WB:1:500-1:5000.
抗体种类	Monoclonal
亚细胞定位	Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm, cytoskeleton. Cleavage furrow. Cytoplasm, cell cortex. Midbody. Cell projection, lamellipodium. Cell projection, dendrite.
构建方式	Recombinant Antibody
纯化方式	Affinity-chromatography
性状	Liquid
缓冲液	Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
研究背景	Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Mainly associated with cytoskeleton organization, in active state binds to a variety of effector proteins to regulate cellular responses such as cytoskeletal dynamics, cell migration and cell cycle. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Regulates KCNA2 potassium channel activity by reducing its location at the cell surface in response to CHRM1 activation; promotes KCNA2 endocytosis. Acts as an allosteric activator of guanine nucleotide exchange factor ECT2 by binding in its activated GTP-bound form to the PH domain of ECT2 which stimulates the release of PH inhibition and promotes the binding of substrate RHOA to the ECT2 catalytic center. May be an activator of PLCE1. In neurons, involved in the inhibiton of the initial spine growth. Upon activation by CaMKII, modulates dendritic spine structural plasticity by relaying CaMKII transient activation to synapse-specific, long-term signaling. Acts as a regulator of platelet alpha-granule release during activation and aggregation of platelets. (Microbial infection) Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague.