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Anti-PTH1R Antibody (6S56) 是一种 Rabbit 抗体,靶向 PTH1R。Anti-PTH1R Antibody (6S56) 可用于 ELISA。
Anti-PTH1R Antibody (6S56) 是一种 Rabbit 抗体,靶向 PTH1R。Anti-PTH1R Antibody (6S56) 可用于 ELISA。
产品描述 | Anti-PTH1R Antibody (6S56) is a Rabbit antibody targeting PTH1R. Anti-PTH1R Antibody (6S56) can be used in ELISA. |
Ig Type | Monoclonal Rabbit IgG |
克隆号 | 6S56 |
交叉反应 | Human |
应用 | ELISA |
推荐剂量 | ELISA: 1:5000-1:10000 |
抗体种类 | Monoclonal |
宿主来源 | Rabbit |
构建方式 | This antibody was obtained from a rabbit immunized with purified, recombinant Human PTH1R / PTHR1 (rh PTH1R / PTHR1; TMPY-02236; Q03431; Met1-Gly188). |
纯化方式 | Protein A |
性状 | Liquid |
缓冲液 | 0.2 μm filtered solution in PBS |
研究背景 | Parathyroid hormone / parathyroid hormone-related peptide receptor, also known as PTH / PTHrP type I receptor, PTH/PTHr receptor, Parathyroid hormone 1 receptor, PTH1 receptor, PTH1R and PTHR, is a multi-pass membrane protein which belongs to the G-protein coupled receptor 2 family. PTH1R is expressed in most tissues. It is most abundant in kidney, bone and liver. PTH1R is expressed in high levels in bone and kidney and regulates calcium ion homeostasis through activation of adenylate cyclase and phospholipase C. In bone, PTH1R is expressed on the surface of osteoblasts. When the receptor is activated, these cells in turn stimulate osteoclasts to ultimately increase the resorption rate. PTH1R is a receptor for parathyroid hormone and for parathyroid hormone-related peptide. The activity of PTH1R is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. Defects in PTH1R are the cause of Jansen metaphyseal chondrodysplasia (JMC), chondrodysplasia Blomstrand type (BOCD), enchondromatosis multiple (ENCHOM), Eiken skeletal dysplasia (EISD) and primary failure of tooth eruption (PFE). |
偶联 | Unconjugated |
免疫原 | Recombinant Human PTH1R / PTHR1 protein (TMPY-02236) |
抗原种属 | Human |
储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
运输方式 | Shipping with blue ice. |
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