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Anti-Prolactin Receptor Antibody (3T541)
还可以产品编号 TMAY-03738
Anti-Prolactin Receptor Antibody (3T541) 是一种 Rabbit 抗体，靶向 Prolactin Receptor。Anti-Prolactin Receptor Antibody (3T541) 可用于 ELISA。
Anti-Prolactin Receptor Antibody (3T541)
Anti-Prolactin Receptor Antibody (3T541)
还可以产品编号 TMAY-03738
Anti-Prolactin Receptor Antibody (3T541) 是一种 Rabbit 抗体，靶向 Prolactin Receptor。Anti-Prolactin Receptor Antibody (3T541) 可用于 ELISA。
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产品介绍
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偶联与修饰
抗原信息
| 产品描述 | Anti-Prolactin Receptor Antibody (3T541) is a Rabbit antibody targeting Prolactin Receptor. Anti-Prolactin Receptor Antibody (3T541) can be used in ELISA. |
| Ig Type | Monoclonal Rabbit IgG |
| 克隆号 | 3T541 |
| 交叉反应 | Rat |
| 应用 | ELISA |
| 推荐剂量 | ELISA: 1:5000-1:10000 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | This antibody was obtained from a rabbit immunized with purified, recombinant Rat Prolactin Receptor / PRLR (rR Prolactin Receptor / PRLR; TMPY-02434; P05710-1; Met1-Asp229). |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | Prolactin receptor (PRLR) is a single-pass transmembrane receptor belonging to the type I cytokine receptor superfamily, and contains two fibronectin type-III domains. All class 1 ligands activate their respective receptors by clustering mechanisms. Ligand binding results in the transmembrane PRLR dimerization, followed by phosphorylation and activation of the molecules involved in the signaling pathways, such as Jak-STAT, Ras/Raf/MAPK. The PRLR contains no intrinsic tyrosine kinase cytoplasmic domain but associates with a cytoplasmic tyrosine kinase, JAK2. PRLR mainly serves as the receptor for the pituitary hormone prolactin (PRL), a secreted hormone that affects reproduction and homeostasis in vertebrates. PRLR can be regulated by an interplay of two different mechanisms, PRL or ovarian steroid hormones independently or in combination in a tissue-specific manner. The role of the hormone prolactin (PRL) in the pathogenesis of breast cancer is mediated by its cognate receptor (PRLR). Ubiquitin-dependent degradation of the PRLR that negatively regulates PRL signaling is triggered by PRL-mediated phosphorylation of PRLR on Ser349 followed by the recruitment of the beta-transducin repeats-containing protein (beta-TrCP) ubiquitin-protein isopeptide ligase. which altered PRLR stability may directly influence the pathogenesis of breast cancer. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Rat Prolactin Receptor / PRLR Protein (TMPY-02434) |
| 抗原种属 | Rat |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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