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Anti-PRKAR2A Polyclonal Antibody 2

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货号 TMAB-11739

Anti-PRKAR2A Polyclonal Antibody 2 是一种 Rabbit 抗体，靶向 PRKAR2A。Anti-PRKAR2A Polyclonal Antibody 2 可用于 WB,ICC/IF,ELISA。

Anti-PRKAR2A Polyclonal Antibody 2

Anti-PRKAR2A Polyclonal Antibody 2

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Rating icon 还可以
货号 TMAB-11739

Anti-PRKAR2A Polyclonal Antibody 2 是一种 Rabbit 抗体，靶向 PRKAR2A。Anti-PRKAR2A Polyclonal Antibody 2 可用于 WB,ICC/IF,ELISA。

规格价格库存数量
50 μL
¥ 1,170
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100 μL
¥ 1,965
5日内发货
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产品介绍

生物活性
产品描述
Anti-PRKAR2A Polyclonal Antibody 2 is a Rabbit antibody targeting PRKAR2A. Anti-PRKAR2A Polyclonal Antibody 2 can be used in WB,ICC/IF,ELISA.
Ig Type
IgG
反应种属
Human,Mouse,Rat
应用WBICC/IFELISA
推荐剂量
WB: 1:500-2000; ICC/IF: 1:50 - 1:200; ELISA: 1:5000-10000
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Cytoplasm. Cell membrane. Note=Co-localizes with PJA2 in the cytoplasm and the cell membrane.
组织特异性Four types of regulatory chains are found: I-alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景The second messenger cyclic AMP (cAMP) mediates diverse cellular responses to external signals such as proliferation, ion transport, regulation of metabolism and gene transcription by activation of the cAMP-dependent protein kinase (cAPK or PKA). Activation of PKA occurs when cAMP binds to the two regulatory subunits of the tetrameric PKA holoenzyme, resulting in release of active catalytic subunits. Activation of transcription upon elevation of cAMP levels results from translocation of PKA to the nucleus, where it phosphorylates the transcription factor cAMP response element binding protein (CREB) on Serine 133, which in turn leads to TFIIB binding to TATA-box-binding protein TBP1, thus linking phospho-CREB to the Pol II transcription initiation complex. Mouse Serine 96 (designated Ser 99 in human) is a phosphorylation site on the PKA II?regulatory subunit.
抗原信息
免疫原
Recombinant Protein: human PRKAR2A
抗原种属
Human
基因名称
PRKAR2A
基因ID
5576
蛋白名称
cAMP-dependent protein kinase type II-alpha regulatory subunit
Uniprot ID
P13861
功能
Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase.
化学信息
分子量Theoretical: 49 kDa.
储存&溶解度
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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