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Anti-PPM1A Antibody (8T936)
还可以产品编号 TMAY-03206
Anti-PPM1A Antibody (8T936) 是一种 Rabbit 抗体，靶向 PPM1A。Anti-PPM1A Antibody (8T936) 可用于 WB。
Anti-PPM1A Antibody (8T936)
Anti-PPM1A Antibody (8T936)
还可以产品编号 TMAY-03206
Anti-PPM1A Antibody (8T936) 是一种 Rabbit 抗体，靶向 PPM1A。Anti-PPM1A Antibody (8T936) 可用于 WB。
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产品介绍
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偶联与修饰
抗原信息
| 产品描述 | Anti-PPM1A Antibody (8T936) is a Rabbit antibody targeting PPM1A. Anti-PPM1A Antibody (8T936) can be used in WB. |
| Ig Type | Monoclonal Rabbit IgG |
| 克隆号 | 8T936 |
| 交叉反应 | Mouse |
| 验证活性 | Anti-PPM1A rabbit monoclonal antibody at 1:500 -Lane A: Jurkat Whole Cell Lysate. -Lane B: MCF7 Whole Cell Lysate. -Lane C: SKBR3 Whole Cell Lysate. -Lane D: Mouse brain Tissue lysate. -Lysates/proteins at 30 μg per lane. -Secondary -Goat Anti-Rabbit IgG H&L (Dylight800) at 1/10000 dilution. -Developed using the Odyssey technique. -Performed under reducing conditions. -Predicted band size:42 kDa. -Observed band size:45 kDa(We are unsure as to the identity of these extra bands.) |
| 应用 | WB |
| 推荐剂量 | WB: 1:500-1:2000 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | This antibody was obtained from a rabbit immunized with purified, recombinant Mouse PPM1A / PP2CA (rM PPM1A / PP2CA; TMPY-01663; NP_032936.1; Met1-Trp382). |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | Protein phosphatase 1A (PPM1A / PP2CA) is an enzyme belonging to the PP2C family of Ser / Thr protein phosphatases. Members of PP2C family are negative regulators of cell stress response pathways and the MAP kinases and MAP kinase kinases. It has also been demonstrated to inhibit the activation of p38 and JNK kinase cascades. PPM1A dephosphorylates and promotes nuclear export of TGFβ-activated Smad2/3. Ectopic expression of PPM1A abolishes TGFβ-induced antiproliferative and transcriptional responses, whereas depletion of PPM1A enhances TGFβ signaling in mammalian cells. It has been demonstrated that PPM1A / PP2CA, through dephosphorylation of Smad2/3, plays a critical role in terminating TGFβ signaling. Overexpression of PPM1A is reported to activate the expression of the tumor suppressor gene TP53 / p53, which leads to cell apoptosis. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Mouse PPM1A / PP2CA Protein (TMPY-01663) |
| 抗原种属 | Mouse |
| 研究领域 | Phosphatases and Regulators |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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