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顶部生物活性储存和溶解信息计算器

Anti-Phospho-Smad2 (Ser250) Polyclonal Antibody 3

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产品编号 TMAB-11294

种类：Rabbit Polyclonal
应用：WB,FCM
交叉反应：Human,Mouse (predicted:Rat,Dog,Pig,Cow)

Anti-Phospho-Smad2 (Ser250) Polyclonal Antibody 3

Anti-Phospho-Smad2 (Ser250) Polyclonal Antibody 3

一键复制产品信息
Rating icon 还可以
产品编号 TMAB-11294

种类：Rabbit Polyclonal
应用：WB,FCM
交叉反应：Human,Mouse (predicted:Rat,Dog,Pig,Cow)

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产品介绍

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产品描述
Anti-Phospho-Smad2 (Ser250) Polyclonal Antibody 3 is a Rabbit antibody targeting Phospho-Smad2 (Ser250). Anti-Phospho-Smad2 (Ser250) Polyclonal Antibody 3 can be used in WB,FCM.
Ig Type
IgG
交叉反应
Human,Mouse (predicted:Rat,Dog,Pig,Cow)
应用WBFCM
推荐剂量
WB: 1:500-2000; FCM: 1μg/Test
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Cytoplasm. Nucleus. Note=Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4. On dephosphorylation by phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1.
组织特异性Expressed at high levels in skeletal muscle, heart and placenta.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液Preservative: 0.02% Proclin300, Constituents: 1% BSA, 0.01M PBS, pH7.4.
浓度1mg/ml
研究背景The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012]
抗原信息
免疫原
KLH conjugated synthesised phosphopeptide: human Smad2 around the phosphorylation site of Ser250
抗原种属
Human
基因名称
SMAD2
基因ID
4087
蛋白名称
Mothers against decapentaplegic homolog 2
Uniprot ID
Q15796
功能
Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.
化学信息
分子量Theoretical: 58 kDa.
存储&运输
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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