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Anti-Phospho-Siglec-2/CD22 (Tyr807) Polyclonal Antibody

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Anti-Phospho-Siglec-2/CD22 (Tyr807) Polyclonal Antibody
产品编号 TMAC-00681
别名 Siglec-2/CD22 (p-Y807), Siglec-2/CD22 (p-Tyr807), p-Siglec-2/CD22 (Y807), p-Siglec-2/CD22 (Tyr807)

Anti-Phospho-Siglec-2/CD22 (Tyr807) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-Siglec-2/CD22 (Tyr807)。Anti-Phospho-Siglec-2/CD22 (Tyr807) Polyclonal Antibody 可用于 WB,IHC-P,IF(paraffin section),ELISA。

Anti-Phospho-Siglec-2/CD22 (Tyr807) Polyclonal Antibody

Anti-Phospho-Siglec-2/CD22 (Tyr807) Polyclonal Antibody

Rating icon 还可以
Anti-Phospho-Siglec-2/CD22 (Tyr807) Polyclonal Antibody
产品编号 TMAC-00681 别名 Siglec-2/CD22 (p-Y807), Siglec-2/CD22 (p-Tyr807), p-Siglec-2/CD22 (Y807), p-Siglec-2/CD22 (Tyr807)

Anti-Phospho-Siglec-2/CD22 (Tyr807) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-Siglec-2/CD22 (Tyr807)。Anti-Phospho-Siglec-2/CD22 (Tyr807) Polyclonal Antibody 可用于 WB,IHC-P,IF(paraffin section),ELISA。

规格价格库存数量
50 μL
¥ 1,490
5日内发货
100 μL
¥ 2,240
5日内发货
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产品介绍

生物活性
产品描述
Anti-Phospho-Siglec-2/CD22 (Tyr807) Polyclonal Antibody is a Rabbit antibody targeting Phospho-Siglec-2/CD22 (Tyr807). Anti-Phospho-Siglec-2/CD22 (Tyr807) Polyclonal Antibody can be used in WB,IHC-P,IF(paraffin section),ELISA.
别名Siglec-2/CD22 (p-Y807), Siglec-2/CD22 (p-Tyr807), p-Siglec-2/CD22 (Y807), p-Siglec-2/CD22 (Tyr807)
Ig Type
IgG
交叉反应
Human
应用
WB
IHC-P
IF(paraffin section)
ELISA
推荐剂量
WB: 1:500-2000; IHC-P: 1:100-300; ELISA: 1:40000
抗体种类
Polyclonal
宿主来源Rabbit
构建方式Polyclonal Antibody
纯化方式The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
性状Liquid
缓冲液Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
研究背景alternative products:Additional isoforms seem to exist,domain:Contains 4 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.,function:Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.,online information:Siglec-2,online information:Siglec-2 [3 Fc Domains],PTM:Phosphorylated on tyrosine residues by LYN.,PTM:Phosphorylation of Tyr-762, Tyr-807 and Tyr-822 are involved in binding to SYK, GRB2 and SYK, respectively. Phosphorylation of Tyr-842 is involved in binding to SYK, PLCG2 and PIK3R1/PIK3R2.,similarity:Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,similarity:Contains 6 Ig-like C2-type (immunoglobulin-like) domains.,subunit:Predominantly monomer of isoform CD22-beta. Also found as heterodimer of isoform CD22-beta and a shorter isoform. Interacts with PTPN6/SHP-1, LYN, SYK, PIK3R1/PIK3R2 and PLCG1 upon phosphorylation. Interacts with GRB2, INPP5D and SHC1 upon phosphorylation (By similarity). May form a complex with INPP5D/SHIP, GRB2 and SHC1.,tissue specificity:B-lymphocytes.,
偶联与修饰
偶联
Unconjugated
其他可选修饰符
Phospho
抗原信息
免疫原
A synthesized phosphopeptide: human BL-CAM around the phosphorylation site of Tyr807. AA range:776-825
抗原种属
human
Uniprot ID
P20273
化学信息
分子量Actual: 95 kDa.
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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关键词

Siglec-2/CD22 (pY807)Siglec-2/CD22 (pTyr807)Siglec-2/CD22 (phospho-Y807)Siglec-2/CD22 (phospho-Tyr807)pSiglec-2/CD22 (Y807)pSiglec-2/CD22 (Tyr807)

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