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顶部生物活性储存和溶解信息计算器

Anti-Phospho-Progesterone Receptor (Ser190) Polyclonal Antibody 2

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产品编号 TMAB-11187

Anti-Phospho-Progesterone Receptor (Ser190) Polyclonal Antibody 2 是一种 Rabbit 抗体，靶向 Phospho-Progesterone Receptor (Ser190)。Anti-Phospho-Progesterone Receptor (Ser190) Polyclonal Antibody 2 可用于 WB,FCM。

Anti-Phospho-Progesterone Receptor (Ser190) Polyclonal Antibody 2

Anti-Phospho-Progesterone Receptor (Ser190) Polyclonal Antibody 2

一键复制产品信息
Rating icon 还可以
产品编号 TMAB-11187

Anti-Phospho-Progesterone Receptor (Ser190) Polyclonal Antibody 2 是一种 Rabbit 抗体，靶向 Phospho-Progesterone Receptor (Ser190)。Anti-Phospho-Progesterone Receptor (Ser190) Polyclonal Antibody 2 可用于 WB,FCM。

规格价格库存数量
50 μL
¥ 1,160
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100 μL
¥ 1,975
5日内发货
200 μL
¥ 2,795
5日内发货
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产品介绍

生物活性
产品描述
Anti-Phospho-Progesterone Receptor (Ser190) Polyclonal Antibody 2 is a Rabbit antibody targeting Phospho-Progesterone Receptor (Ser190). Anti-Phospho-Progesterone Receptor (Ser190) Polyclonal Antibody 2 can be used in WB,FCM.
Ig Type
IgG
交叉反应
Human,Rat (predicted:Mouse,Cow)
应用WBFCM
推荐剂量
WB: 1:500-2000; FCM: 1μg/Test
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Nucleus. Cytoplasm. Note=Nucleoplasmic shuttling is both homone- and cell cycle-dependent. On hormone stimulation, retained in the cytoplasm in the G(1) and G(2)/M phases. Isoform A: Nucleus. Cytoplasm. Note=Mainly nuclear.
组织特异性Isoform A: Nucleus. Cytoplasm. Note=Mainly nuclear.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景Estrogen and progesterone receptor are members of a family of transcription factors that are regulated by the binding of their cognate ligands. The interaction of hormone-bound estrogen receptors with estrogen responsive elements(EREs) alters transcription of ERE-containing genes. The carboxy terminal region of the estrgen receptor contains the ligand binding domain, the amino terminus serves as the transactivation domain, and the DNA binding domain is centrally located. Two forms of estrogen receptor have been identified, ER alpha and ER beta. ER alpha and ER beta have been shown to be differentially activated by various ligands. The biological response to progesterone is mediated by two distinct forms of the human progesterone receptor (hPR-Aand hPR-B), which arise from alternative splicing. In most cells, hPR-B functions as a transcriptional activator of progesterone-responsive gene, whereas hPR-A function as a transcriptional inhibitor of all steroid hormone receptors.
抗原信息
免疫原
KLH conjugated Synthesised phosphopeptide: rat Progesterone Receptor around the phosphorylation site of Ser190
抗原种属
Rat
基因名称
PGR
基因ID
25154
蛋白名称
Progesterone receptor
Uniprot ID
Q63449
功能
The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Progesterone receptor isoform B (PRB) is involved activation of c-SRC/MAPK signaling on hormone stimulation.
Isoform A is inactive in stimulating c-Src/MAPK signaling on hormone stimulation.
化学信息
分子量Theoretical: 99 kDa.
存储&运输
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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