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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-Phospho-PKR (Thr446) Polyclonal Antibody

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货号 TMAB-11162

Anti-Phospho-PKR (Thr446) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-PKR (Thr446)。Anti-Phospho-PKR (Thr446) Polyclonal Antibody 可用于 WB,IHC-P,IHC-Fr,IF,FCM。

Anti-Phospho-PKR (Thr446) Polyclonal Antibody

Anti-Phospho-PKR (Thr446) Polyclonal Antibody

一键复制产品信息
Rating icon 还可以
货号 TMAB-11162

Anti-Phospho-PKR (Thr446) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-PKR (Thr446)。Anti-Phospho-PKR (Thr446) Polyclonal Antibody 可用于 WB,IHC-P,IHC-Fr,IF,FCM。

规格价格库存数量
50 μL
¥ 1,175
5日内发货
100 μL
¥ 1,965
5日内发货
200 μL
¥ 2,785
5日内发货
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产品介绍

生物活性
产品描述
Anti-Phospho-PKR (Thr446) Polyclonal Antibody is a Rabbit antibody targeting Phospho-PKR (Thr446). Anti-Phospho-PKR (Thr446) Polyclonal Antibody can be used in WB,IHC-P,IHC-Fr,IF,FCM.
Ig Type
IgG
反应种属
Human,Rat (predicted:Mouse)
应用WBIHC-PIHC-FrIFFCM
推荐剂量
WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500; FCM: 2μg/Test
抗体种类
Polyclonal
宿主来源Rabbit
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景PKR is an interferon-inducible serine/threonine specific protein kinase. It is widely expressed in eukaryotic organisms and activated by double stranded RNA. Activation of PKR by dsRNAs leads to autophosphorylation at multiple sites. Phosphorylation of Thr446 and Thr451 in the PKR activation loop is required in vivo and in vitro for high level kinase activity. PKR phosphorylates its natural substrate, the alpha subunit of eukaryotic protein synthesis initiation factor 2 (EIF2 alpha), leading to the inhibition of protein synthesis. PKR is also involved in TLR signaling and mediates apoptosis in fibroblasts in response to viral infection and inflammatory cytokines, and also activates IKK and NFKB, thereby suppressing apoptosis. Recently, it has been reported that PKR also phosphorylates human p53 on serine 392. PKR might play a role in ER stress-induced apoptosis and in Alzheimer's disease. Alzheimer cases show prominent PKR activation in association with neuritic plaques and pyramidal neurons in the hippocampus and neocortex.
抗原信息
免疫原
KLH conjugated Synthesised phosphopeptide: human PKR around the phosphorylation site of Thr446
抗原种属
Human
基因名称
EIF2AK2
基因ID
5610
蛋白名称
Interferon-induced, double-stranded RNA-activated protein kinase
Uniprot ID
P19525
功能
Following activation by double-stranded RNA in the presence of ATP, the kinase becomes autophosphorylated and can catalyze the phosphorylation of the translation initiation factor EIF2S1, which leads to an inhibition of the initiation of protein synthesis. Double-stranded RNA is generated during the course of a viral infection.
化学信息
分子量Theoretical: 62 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

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