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顶部生物活性储存和溶解信息计算器

Anti-Phospho-p53BP1 (Ser25+Ser29) Polyclonal Antibody

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产品编号 TMAB-11090

Anti-Phospho-p53BP1 (Ser25+Ser29) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-p53BP1 (Ser25+Ser29)。Anti-Phospho-p53BP1 (Ser25+Ser29) Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

Anti-Phospho-p53BP1 (Ser25+Ser29) Polyclonal Antibody

Anti-Phospho-p53BP1 (Ser25+Ser29) Polyclonal Antibody

一键复制产品信息
Rating icon 还可以
产品编号 TMAB-11090

Anti-Phospho-p53BP1 (Ser25+Ser29) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-p53BP1 (Ser25+Ser29)。Anti-Phospho-p53BP1 (Ser25+Ser29) Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

规格价格库存数量
50 μL
¥ 1,165
5日内发货
100 μL
¥ 1,965
5日内发货
200 μL
¥ 2,795
5日内发货
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产品介绍

生物活性
产品描述
Anti-Phospho-p53BP1 (Ser25+Ser29) Polyclonal Antibody is a Rabbit antibody targeting Phospho-p53BP1 (Ser25+Ser29). Anti-Phospho-p53BP1 (Ser25+Ser29) Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Ig Type
IgG
交叉反应
Mouse,Rat (predicted:Human,Dog,Pig,Cow,Horse,Rabbit)
应用IHC-PIHC-FrIF
推荐剂量
IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Nucleus. Chromosome; centromere; kinetochore. Associated with kinetochores. Both nuclear and cytoplasmic in some cells. Recruited to sites of DNA damage, such as double stand breaks. Methylation of histone H4 at 'Lys-20' is required for efficient localization to double strand breaks.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景p53 binding protein 1 (53BP1) plays a critical role in tumor suppression and is a putative substrate of ATM kinase. Upon DNA damage, it is phosphorylated and relocalizes to the presumptive sites of damage, p53 binding protein 1 (53BP1) plays a critical role in tumor suppression and is a putative substrate of ATM kinase. Upon DNA damage, it is phosphorylated and relocalizes to the presumptive sites of damage, specifically, double strand breaks. This also suggests a role in DNA repair, maintaining genomic stability.
抗原信息
免疫原
KLH conjugated Synthesised phosphopeptide: human p53BP1 around the phosphorylation site of Ser25/29
抗原种属
Human
基因名称
TP53BP1
基因ID
7158
蛋白名称
TP53-binding protein 1
Uniprot ID
Q12888
功能
May have a role in checkpoint signaling during mitosis. Enhances TP53-mediated transcriptional activation. Plays a role in the response to DNA damage.
化学信息
分子量Theoretical: 213 kDa.
存储&运输
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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