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顶部生物活性储存和溶解信息计算器

Anti-Phospho-MEF2A (Thr319) Polyclonal Antibody 2

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产品编号 TMAB-10971

Anti-Phospho-MEF2A (Thr319) Polyclonal Antibody 2 是一种 Rabbit 抗体，靶向 Phospho-MEF2A (Thr319)。Anti-Phospho-MEF2A (Thr319) Polyclonal Antibody 2 可用于 WB。

Anti-Phospho-MEF2A (Thr319) Polyclonal Antibody 2

Anti-Phospho-MEF2A (Thr319) Polyclonal Antibody 2

一键复制产品信息
Rating icon 还可以
产品编号 TMAB-10971

Anti-Phospho-MEF2A (Thr319) Polyclonal Antibody 2 是一种 Rabbit 抗体，靶向 Phospho-MEF2A (Thr319)。Anti-Phospho-MEF2A (Thr319) Polyclonal Antibody 2 可用于 WB。

规格价格库存数量
50 μL
¥ 1,175
5日内发货
100 μL
¥ 1,975
5日内发货
200 μL
¥ 2,785
5日内发货
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产品介绍

生物活性
产品描述
Anti-Phospho-MEF2A (Thr319) Polyclonal Antibody 2 is a Rabbit antibody targeting Phospho-MEF2A (Thr319). Anti-Phospho-MEF2A (Thr319) Polyclonal Antibody 2 can be used in WB.
Ig Type
IgG
交叉反应
Mouse,Rat (predicted:Human,Dog,Cow,Horse,Sheep)
应用WB
推荐剂量
WB: 1:500-2000
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Nucleus.
组织特异性Isoform MEF2 and isoform MEFA are expressed only in skeletal and cardiac muscle and in the brain. Isoform RSRFC4 and isoform RSRFC9 are expressed in all tissues examined.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景The process of differentiation from mesodermal precursor cells to myoblasts has led to the discovery of a variety of tissue-specific factors that regulate muscle gene expression. The myogenic basic helix-loop-helix proteins, including myoD (MIM 159970), myogenin (MIM 159980), MYF5 (MIM 159990), and MRF4 (MIM 159991) are one class of identified factors. A second family of DNA binding regulatory proteins is the myocyte-specific enhancer factor-2 (MEF2) family. Each of these proteins binds to the MEF2 target DNA sequence present in the regulatory regions of many, if not all, muscle-specific genes. The MEF2 genes are members of the MADS gene family (named for the yeast mating type-specific transcription factor MCM1, the plant homeotic genes 'agamous' and 'deficiens' and the human serum response factor SRF (MIM 600589)), a family that also includes several homeotic genes and other transcription factors, all of which share a conserved DNA-binding domain. MEF2A belongs to a family of DNA binding regulatory proteins. The MEF2 family of transcription factors is highly expressed in the brain when neurons undergo dendritic maturation and synapse formation. MEF2A is especially abundant in granule neurons of the cerebellar cortex throughout the period of synaptogenesis. MEF2A also has key roles in cardiac and skeletal muscle development.
抗原信息
免疫原
KLH conjugated Synthesised phosphopeptide: human MEF2A around the phosphorylation site of Thr319
抗原种属
Human
基因名称
MEF2A
基因ID
4205
蛋白名称
Myocyte-specific enhancer factor 2A
Uniprot ID
Q02078
功能
Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Also involved in the activation of numerous growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. In cerebellar granule neurons, phosphorylated and sumoylated MEF2A represses transcription of NUR77 promoting synaptic differentiation.
化学信息
分子量Theoretical: 54 kDa.
存储&运输
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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