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Anti-Phospho-Gab1 (Tyr627) Polyclonal Antibody 2

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产品编号 TMAB-10724

Anti-Phospho-Gab1 (Tyr627) Polyclonal Antibody 2 是一种 Rabbit 抗体，靶向 Phospho-Gab1 (Tyr627)。Anti-Phospho-Gab1 (Tyr627) Polyclonal Antibody 2 可用于 WB。

Anti-Phospho-Gab1 (Tyr627) Polyclonal Antibody 2

Anti-Phospho-Gab1 (Tyr627) Polyclonal Antibody 2

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Rating icon 还可以
产品编号 TMAB-10724

Anti-Phospho-Gab1 (Tyr627) Polyclonal Antibody 2 是一种 Rabbit 抗体，靶向 Phospho-Gab1 (Tyr627)。Anti-Phospho-Gab1 (Tyr627) Polyclonal Antibody 2 可用于 WB。

规格价格库存数量
50 μL
¥ 1,175
5日内发货
100 μL
¥ 1,975
5日内发货
200 μL
¥ 2,780
5日内发货
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产品介绍

生物活性
产品描述
Anti-Phospho-Gab1 (Tyr627) Polyclonal Antibody 2 is a Rabbit antibody targeting Phospho-Gab1 (Tyr627). Anti-Phospho-Gab1 (Tyr627) Polyclonal Antibody 2 can be used in WB.
Ig Type
IgG
交叉反应
Mouse,Rat (predicted:Human,Chicken,Dog,Pig,Cow,Horse)
应用WB
推荐剂量
WB: 1:500-2000
抗体种类
Polyclonal
宿主来源Rabbit
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景Gab1 is a 115 kDa multiple docking protein that plays an essential role in cellular growth, transformation and apoptosis. Gab1 can be phosphorylated by multiple receptor tyrosine kinase (RTKs), including: insulin receptor (IR), platelet derived growth factor receptor beta] (PDGFRbeta]), hepatocyte growth factor/scatter factor receptor (HGFR/SFR or c Met), and epidermal growth factor receptor (EGF), as well as in response to cell cell adhesion. Gab1 is tyrosine phosphorylated on at least 16 sites, some of which serve as binding sites for phosphoatidylinositol 3 kinase (PI3K), Grb2, PLC gamma 1, Nck, and SHP2. Phosphorylation of Gab1 on tyrosines 627 and 659 is critical for its binding to SHP2, and for activation of the ERK/MAPK pathway in response to EGF.
抗原信息
免疫原
KLH conjugated Synthesised phosphopeptide: human Gab1 around the phosphorylation site of Tyr627
抗原种属
Human
基因名称
GAB1
基因ID
2549
蛋白名称
GRB2-associated-binding protein 1
Uniprot ID
Q13480
功能
Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR).
化学信息
分子量Theoretical: 76 kDa.
存储&运输
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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