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顶部生物活性储存和溶解信息计算器

Anti-Phospho-CSK (Ser364) Polyclonal Antibody 2

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产品编号 TMAB-10550

Anti-Phospho-CSK (Ser364) Polyclonal Antibody 2 是一种 Rabbit 抗体，靶向 Phospho-CSK (Ser364)。Anti-Phospho-CSK (Ser364) Polyclonal Antibody 2 可用于 IHC-P,IHC-Fr,IF。

Anti-Phospho-CSK (Ser364) Polyclonal Antibody 2

Anti-Phospho-CSK (Ser364) Polyclonal Antibody 2

一键复制产品信息
Rating icon 还可以
产品编号 TMAB-10550

Anti-Phospho-CSK (Ser364) Polyclonal Antibody 2 是一种 Rabbit 抗体，靶向 Phospho-CSK (Ser364)。Anti-Phospho-CSK (Ser364) Polyclonal Antibody 2 可用于 IHC-P,IHC-Fr,IF。

规格价格库存数量
50 μL
¥ 1,170
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100 μL
¥ 1,965
5日内发货
200 μL
¥ 2,790
5日内发货
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产品介绍

生物活性
产品描述
Anti-Phospho-CSK (Ser364) Polyclonal Antibody 2 is a Rabbit antibody targeting Phospho-CSK (Ser364). Anti-Phospho-CSK (Ser364) Polyclonal Antibody 2 can be used in IHC-P,IHC-Fr,IF.
Ig Type
IgG
交叉反应
Human,Rat (predicted:Mouse,Chicken,Pig,Cow,Horse,Sheep)
应用IHC-PIHC-FrIF
推荐剂量
IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Cytoplasm. Cell membrane. Mainly cytoplasmic, also present in lipid rafts.
组织特异性Expressed in lung and macrophages.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景All members of the Src gene family of tyrosine kinases are characterized by a carboxy terminal domain tyrosine which is highly phosphorylated in the inactive form of the enzyme and phosphorylated to a much lesser extent when the enzyme is active. In the case of Src p60, Y527 is this tyrosine; however, a mutant form of c-Src in which Y527 is replaced by phenylalanine is transforming and displays 5- to 10-fold elevated kinase activity compared to its normal counterpart. Csk has been identified as a Src-related tyrosine kinase having both SH2 and SH3 domains and a catalytic domain but lacking sequences amino terminal to the SH3 domain as well as carboxy terminal regulatory sequences. Csk phosphorylates Src on Y527 and also downregulates Lyn, Fyn and Lck by tyrosine phosphorylation of carboxy terminal regulatory sites.
抗原信息
免疫原
KLH conjugated synthesised phosphopeptide: human CSK around the phosphorylation site of Ser364
抗原种属
Human
基因名称
CSK
基因ID
1445
蛋白名称
Tyrosine-protein kinase CSK
Uniprot ID
P41240
功能
Specifically phosphorylates 'Tyr-504' on LCK, which acts as a negative regulatory site. Can also act on the LYN and FYN kinases.
化学信息
分子量Theoretical: 51 kDa.
存储&运输
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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