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Anti-Phospho-APC (Ser2054) Polyclonal Antibody 2
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还可以产品编号 TMAB-10323
Anti-Phospho-APC (Ser2054) Polyclonal Antibody 2 是一种 Rabbit 抗体，靶向 Phospho-APC (Ser2054)。Anti-Phospho-APC (Ser2054) Polyclonal Antibody 2 可用于 IHC-P,IHC-Fr,IF。
Anti-Phospho-APC (Ser2054) Polyclonal Antibody 2
Anti-Phospho-APC (Ser2054) Polyclonal Antibody 2
一键复制产品信息 还可以产品编号 TMAB-10323
Anti-Phospho-APC (Ser2054) Polyclonal Antibody 2 是一种 Rabbit 抗体，靶向 Phospho-APC (Ser2054)。Anti-Phospho-APC (Ser2054) Polyclonal Antibody 2 可用于 IHC-P,IHC-Fr,IF。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,160 | 5日内发货 | |
| 100 μL | ¥ 1,970 | 5日内发货 | |
| 200 μL | ¥ 2,780 | 5日内发货 |
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| 产品描述 | Anti-Phospho-APC (Ser2054) Polyclonal Antibody 2 is a Rabbit antibody targeting Phospho-APC (Ser2054). Anti-Phospho-APC (Ser2054) Polyclonal Antibody 2 can be used in IHC-P,IHC-Fr,IF. |
| Ig Type | IgG |
| 交叉反应 | Mouse,Rat (predicted:Human,Dog,Pig,Cow,Rabbit,Sheep) |
| 应用 | IHC-PIHC-FrIF |
| 推荐剂量 | IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500 |
| 抗体种类 | Polyclonal |
| 宿主来源 | Rabbit |
| 亚细胞定位 | Cell junction, adherens junction. Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Cell projection, ruffle membrane. Cytoplasm. Cell membrane. Note=Associated with the microtubule network at the growing distal tip of microtubules. Accumulates in the lamellipodium and ruffle membrane in response to hepatocyte growth factor (HGF) treatment. The MEMO1-RHOA-DIAPH1 signaling pathway controls localization of the phosophorylated form to the cell membrane. |
| 组织特异性 | Expressed in a variety of tissues. |
| 构建方式 | Hybridoma Polyclonal Antibody |
| 纯化方式 | Protein A purified |
| 性状 | Liquid |
| 缓冲液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 浓度 | 1mg/ml |
| 研究背景 | This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product. [provided by RefSeq]. |
| 免疫原 | KLH conjugated synthesised phosphopeptide: human APC around the phosphorylation site of Ser2054 |
| 抗原种属 | Human |
| 基因名称 | APC |
| 基因ID | |
| 蛋白名称 | Adenomatous polyposis coli protein |
| Uniprot ID | |
| 功能 | Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization. |
| 分子量 | Theoretical: 312 kDa. |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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