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Anti-PDGFRA Antibody (5Q226)

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Anti-PDGFRA Antibody (5Q226)
产品编号 TMAY-03579
别名 platelet-derived growth factor receptor, α polypeptide, platelet-derived growth factor receptor, alpha polypeptide

Anti-PDGFRA Antibody (5Q226) 是一种 Rabbit 抗体，靶向 PDGFRA。Anti-PDGFRA Antibody (5Q226) 可用于 ELISA,IHC-P。

Anti-PDGFRA Antibody (5Q226)
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Anti-PDGFRA Antibody (5Q226)

Rating icon 还可以
Anti-PDGFRA Antibody (5Q226)
产品编号 TMAY-03579 别名 platelet-derived growth factor receptor, α polypeptide, platelet-derived growth factor receptor, alpha polypeptide

Anti-PDGFRA Antibody (5Q226) 是一种 Rabbit 抗体，靶向 PDGFRA。Anti-PDGFRA Antibody (5Q226) 可用于 ELISA,IHC-P。

规格价格库存数量
100 μL
¥ 1,689
5日内发货
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产品介绍

生物活性
产品描述
Anti-PDGFRA Antibody (5Q226) is a Rabbit antibody targeting PDGFRA. Anti-PDGFRA Antibody (5Q226) can be used in ELISA,IHC-P.
别名platelet-derived growth factor receptor, α polypeptide, platelet-derived growth factor receptor, alpha polypeptide
Ig Type
Rabbit IgG
克隆号
5Q226
交叉反应
Mouse
验证活性
1. Immunochemical staining of Mouse PDGFRA in Mouse blindgut with rabbit monoclonal antibody at 1:200 dilution, formalin-fixed paraffin embedded sections.
2. Immunochemical staining of Mouse PDGFRA in Mouse uterus with rabbit monoclonal antibody at 1:200 dilution, formalin-fixed paraffin embedded sections.
应用
ELISA,IHC-P
推荐剂量
ELISA: 1:5000-1:10000; IHC-P: 1:100-1:500
抗体种类
Monoclonal
宿主来源Rabbit
构建方式This antibody was obtained from a rabbit immunized with purified, recombinant Mouse PDGF alpha receptor/PDGFRA (rM PDGF alpha receptor/PDGFRA; TMPY-05787; NP_001334647.1; Met1-Ala528).
纯化方式Protein A
性状Liquid
缓冲液0.2 μm filtered solution in PBS
研究背景PDGFRA, also known as CD140a, together with the structurally homolog protein PDGFRB (CD140b), are cell surface receptors for members of the platelet-derived growth factor family. They are members of the class III subfamily of receptor tyrosine kinase (RTKs) with the similar structure characteristics of five immunoglobulin-like domains in their extracellular region and a split kinase domain in their intracellular region. PDGFRA is expressed in oligodendrocyte progenitor cells and mesothelial cell, and binds all three ligand isoforms PDGF-AA, PDGF-BB and PDGF-AB with high affinity, whereas PDGFRB dose not bind PDGF-AA. PDGFRA plays an essential role in regulating proliferation, chemotaxis and migration of mesangial cells. Recent studies have indicated that PDGFRA acts as a critical mediator of signaling in testis organogenesis and Leydig cell differentiation, and in addition, particularly important for kidney development. Additionally, PDGFRA is involved in tumor angiogenesis and maintenance of the tumor microenvironment and has been implicated in development and metastasis of Hepatocellular carcinoma (HCC). PDGFRA may represent a potential therapeutic target in thymic tumours. PDGFRA gene amplification rather than gene mutation may be the underlying genetic mechanism driving PDGFRA overexpression in a portion of gliomas.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Recombinant Protein: Mouse PDGF alpha receptor/PDGFRA Protein (TMPY-05787)
抗原种属
Mouse
研究领域
Cancer Drug Targets, Receptor Tyrosine Kinases (RTKs)
存储&运输
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
运输方式Shipping with blue ice.

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