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Anti-PD-L1 Antibody (7I775)
还可以产品编号 TMAY-00239
Anti-PD-L1 Antibody (7I775) 是一种 Mouse 抗体，靶向 PD-L1。Anti-PD-L1 Antibody (7I775) 可用于 IHC-P。
Anti-PD-L1 Antibody (7I775)
Anti-PD-L1 Antibody (7I775)
还可以产品编号 TMAY-00239
Anti-PD-L1 Antibody (7I775) 是一种 Mouse 抗体，靶向 PD-L1。Anti-PD-L1 Antibody (7I775) 可用于 IHC-P。
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抗原信息
| 产品描述 | Anti-PD-L1 Antibody (7I775) is a Mouse antibody targeting PD-L1. Anti-PD-L1 Antibody (7I775) can be used in IHC-P. |
| Ig Type | Monoclonal Mouse IgG1 |
| 克隆号 | 7I775 |
| 交叉反应 | Human |
| 验证活性 | 1. Immunochemical staining of human CD274 in human breast carcinoma with mouse monoclonal antibody at 1:20000 dilution, formalin-fixed paraffin embedded sections. 2. Immunochemical staining of human CD274 in human placenta with mouse monoclonal antibody at 1:20000 dilution, formalin-fixed paraffin embedded sections. |
| 应用 | IHC-P |
| 推荐剂量 | IHC-P: 1:2000-1:20000 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This product is a recombinant monoclonal antibody expressed from HEK293 cells. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | Programmed death-1 ligand-1 (PD-L1, CD274, B7-H1) has been identified as the ligand for the immunoinhibitory receptor programmed death-1(PD1/PDCD1) and has been demonstrated to play a role in the regulation of immune responses and peripheral tolerance. PD-L1/B7-H1 is a member of the growing B7 family of immune molecules and this protein contains one V-like and one C-like Ig domain within the extracellular domain, and together with PD-L2, are two ligands for PD1 which belongs to the CD28/CTLA4 family expressed on activated lymphoid cells. By binding to PD1 on activated T-cells and B-cells, PD-L1 may inhibit ongoing T-cell responses by inducing apoptosis and arresting cell-cycle progression. Accordingly, it leads to growth of immunogenic tumor growth by increasing apoptosis of antigen specific T cells and may contribute to immune evasion by cancers. PD-L1 thus is regarded as promising therapeutic target for human autoimmune disease and malignant cancers.Cancer ImmunotherapyCo-inhibitory Immune Checkpoint TargetsImmune CheckpointImmune Checkpoint Blockade: Blocking AntibodiImmune Checkpoint Blockade: PD-L1 / B7-H1 / CImmune Checkpoint Detection: AntibodiesImmune Checkpoint Detection: ELISA AntibodiesImmune Checkpoint Detection: FCM AntibodiesImmune Checkpoint Detection: ICC AntibodiesImmune Checkpoint Detection: IHC AntibodiesImmune Checkpoint Detection: WB AntibodiesImmune Checkpoint ProteinsImmune Checkpoint TargetsImmunotherapyPD-L1 / B7-H1 / CD274 Immune Checkpoint ProteTargeted Therapy |
| 偶联 | Unconjugated |
| 免疫原 | Full length human CD274 expression plasmid |
| 抗原种属 | Human |
| 研究领域 | Cancer Drug Targets |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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