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Anti-Notch 1 Antibody (3W929)
还可以产品编号 TMAH-00820
别名 TAN1, notch 1, hN1, AOVD1, AOS5
Anti-Notch 1 Antibody (3W929) 是一种抗体，靶向 Notch 1。Anti-Notch 1 Antibody (3W929) 可用于 ELISA, WB, IHC。
Anti-Notch 1 Antibody (3W929)
Anti-Notch 1 Antibody (3W929)
还可以产品编号 TMAH-00820 别名 TAN1, notch 1, hN1, AOVD1, AOS5
Anti-Notch 1 Antibody (3W929) 是一种抗体，靶向 Notch 1。Anti-Notch 1 Antibody (3W929) 可用于 ELISA, WB, IHC。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,310 | 5日内发货 | |
| 100 μL | ¥ 2,180 | 5日内发货 |
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-Notch 1 Antibody (3W929) is an antibody targeting Notch 1. Anti-Notch 1 Antibody (3W929) can be used in ELISA, WB, IHC. |
| 别名 | TAN1, notch 1, hN1, AOVD1, AOS5 |
| Ig Type | Rabbit IgG |
| 克隆号 | 3W929 |
| 交叉反应 | Human |
| 验证活性 | 1. Western Blot -Positive WB detected in: HepG2 whole cell lysate, THP-1 whole cell lysate, HL-60 whole cell lysate -All lanes: Notch1 antibody at 1:1000 -Secondary: Goat polyclonal to rabbit IgG at 1/50000 dilution -Predicted band size: 273 kDa -Observed band size: 120 kDa 2. IHC image of TMAH-00820 diluted at 1:100 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB. |
| 应用 | ELISA, WB, IHC |
| 推荐剂量 | WB:1:500-1:5000; IHC:1:50-1:200. |
| 抗体种类 | Monoclonal |
| 亚细胞定位 | Cell membrane; Single-pass type I membrane protein.; [Notch 1 intracellular domain]: Nucleus. |
| 构建方式 | Recombinant Antibody |
| 纯化方式 | Affinity-chromatography |
| 性状 | Liquid |
| 缓冲液 | Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| 研究背景 | Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4(+) and CD8(+) cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation. May be involved in mesoderm development, somite formation and neurogenesis. May enhance HIF1A function by sequestering HIF1AN away from HIF1A. Required for the THBS4 function in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury. Involved in determination of left/right symmetry by modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO). |
| 偶联 | Unconjugated |
| 免疫原 | A synthetic peptide: Human Notch1 |
| 抗原种属 | Human |
| 基因ID | 4851 |
| Uniprot ID | |
| 研究领域 | Epigenetics and Nuclear Signaling, Neuroscience, Cardiovascular, Developmental biology, Stem cells |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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