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Anti-NOBOX Polyclonal Antibody

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货号 TMAB-09549

Anti-NOBOX Polyclonal Antibody 是一种 Rabbit 抗体，靶向 NOBOX。Anti-NOBOX Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

Anti-NOBOX Polyclonal Antibody

Anti-NOBOX Polyclonal Antibody

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Rating icon 还可以
货号 TMAB-09549

Anti-NOBOX Polyclonal Antibody 是一种 Rabbit 抗体，靶向 NOBOX。Anti-NOBOX Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

规格价格库存数量
50 μL
¥ 1,175
5日内发货
100 μL
¥ 1,965
5日内发货
200 μL
¥ 2,795
5日内发货
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产品介绍

生物活性
产品描述
Anti-NOBOX Polyclonal Antibody is a Rabbit antibody targeting NOBOX. Anti-NOBOX Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Ig Type
IgG
反应种属
Rat (predicted:Mouse)
应用IHC-PIHC-FrIF
推荐剂量
IHC-P: 1:400-800; IHC-Fr: 1:400-800; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Nucleus.
组织特异性Expressed in ovaries, testes and pancreas. Expressed within all stages of the adult female germline, from primordial follicles through to MII oocytes.
构建方式Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景Early ovarian folliculogenesis is characterized by the breakdown of germ cell clusters and formation of primordial follicles. The cessation of ovarian function under the age of 40 years results in premature ovarian failure (POF) and is accompanied by amenorrhea, hypoestrogenism and elevated serum gonadotropin concentrations. 1% of all women are affected by POF, and mutations in a few genes, including inhibin? fsh receptor and the LH/choriogonadotropin receptor have been linked to POF. In addition, several germ cell specific genes and downstream transcription factors are thought to play and important role in human oogenesis. NOBOX (newborn ovary homeobox gene), an ooctye-specific homeobox gene, is a critical protein involved in early folliculogenesis. Missense mutations have been shown to cause nonsyndromic ovarian failure by disrupting the NOBOX proteins ability to bind to NOBOX DNA-binding element (NBE), and thereby inhibiting its regulation of Pou5f1 and GDF-9. NOBOX expression in the ovary is oocyte specific, but it shows expression in adult testis and pancreas as well.
抗原信息
免疫原
KLH conjugated synthetic peptide: mouse NOBOX
抗原种属
Mouse
基因名称
NOBOX
基因ID
135935
蛋白名称
Homeobox protein NOBOX
功能
Transcription factor which may play a role in oogenesis. Binds preferentially to the DNA sequences 5'-TAATTG-3', 5'-TAGTTG-3' and 5'-TAATTA-3'.
化学信息
分子量Theoretical: 57 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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