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Anti-Nectin-3 Antibody (6X959)
还可以产品编号 TMAY-01253
别名 PVRR3, PVRL3, PRR3, PPR3, poliovirus receptor-related 3, nectin-3, FLJ90624, DKFZp566B0846, CDw113, CD113
Anti-Nectin-3 Antibody (6X959) 是一种 Mouse 抗体，靶向 Nectin-3。Anti-Nectin-3 Antibody (6X959) 可用于 IHC-P。
Anti-Nectin-3 Antibody (6X959)
Anti-Nectin-3 Antibody (6X959)
还可以产品编号 TMAY-01253 别名 PVRR3, PVRL3, PRR3, PPR3, poliovirus receptor-related 3, nectin-3, FLJ90624, DKFZp566B0846, CDw113, CD113
Anti-Nectin-3 Antibody (6X959) 是一种 Mouse 抗体，靶向 Nectin-3。Anti-Nectin-3 Antibody (6X959) 可用于 IHC-P。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 100 μL | ¥ 1,679 | 5日内发货 |
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抗原信息
| 产品描述 | Anti-Nectin-3 Antibody (6X959) is a Mouse antibody targeting Nectin-3. Anti-Nectin-3 Antibody (6X959) can be used in IHC-P. |
| 别名 | PVRR3, PVRL3, PRR3, PPR3, poliovirus receptor-related 3, nectin-3, FLJ90624, DKFZp566B0846, CDw113, CD113 |
| Ig Type | Monoclonal Mouse IgG1 |
| 克隆号 | 6X959 |
| 交叉反应 | Human, Cynomolgus |
| 验证活性 | 1. Immunochemical staining PVRL3 in human placenta with mouse monoclonal antibody (1:60, formalin-fixed paraffin embedded sections). 2. Immunochemical staining PVRL3 in human hepatoma with mouse monoclonal antibody (1:60, formalin-fixed paraffin embedded sections). 3. Immunochemical staining PVRL3 in cynomolgus testis with mouse monoclonal antibody (1:60, formalin-fixed paraffin embedded sections). |
| 应用 | IHC-P |
| 推荐剂量 | IHC-P: 1:50-1:200 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD113 / Nectin-3 (rh CD113 / Nectin-3; TMPY-01154; NP_056295.1; Met1-Asp400). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | Poliovirus receptor-related 3 (PVRL3), also known as Nectin-3 and CD113, is a member of the nectin family. PVRL3/Nectin-3 is an 83 kDa, type I transmembrane glycoprotein. Its precursor is 549 amino acids (aa) in length and contains an extended signal sequence of 57 aa, an extracellular domain (ECD) of 347 aa, a transmembrane segment of 21 aa, and a cytoplasmic region of 124 aa. Nectin-3 has three splicing variants, nectin-3alpha (biggest), -3beta (middle), and -3gamma (smallest). It is predominantly expressed in testis and placenta as well as in various cell lines, including epithelial cell lines. PVRL3/Nectin-3 plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with PVRL2/Nectin-2 at Sertoli-spermatid junctions. PVRL3/Nectin-3 is thus involved in the formation of cell-cell junctions, including adherens junctions and synapses. It has been shown to induce endocytosis-mediated down-regulation of PVR from the cell surface, resulting in the reduction of cell movement and proliferation. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Human CD113 / Nectin-3 protein (TMPY-01154) |
| 抗原种属 | Human |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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