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顶部生物活性储存和溶解信息计算器

Anti-MERTK/Mer Antibody (7Y17)

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Anti-MERTK/Mer Antibody (7Y17)
产品编号 TMAY-00582
别名 Tyro12, RP38, MGC133349, MERTK, MER, c-mer, c-Eyk

Anti-MERTK/Mer Antibody (7Y17) 是一种 Mouse 抗体，靶向 MERTK/Mer。Anti-MERTK/Mer Antibody (7Y17) 可用于 ELISA。

Anti-MERTK/Mer Antibody (7Y17)

Anti-MERTK/Mer Antibody (7Y17)

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Anti-MERTK/Mer Antibody (7Y17)
产品编号 TMAY-00582 别名 Tyro12, RP38, MGC133349, MERTK, MER, c-mer, c-Eyk

Anti-MERTK/Mer Antibody (7Y17) 是一种 Mouse 抗体，靶向 MERTK/Mer。Anti-MERTK/Mer Antibody (7Y17) 可用于 ELISA。

规格价格库存数量
100 μL
¥ 1,679
5日内发货
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产品介绍

生物活性
产品描述
Anti-MERTK/Mer Antibody (7Y17) is a Mouse antibody targeting MERTK/Mer. Anti-MERTK/Mer Antibody (7Y17) can be used in ELISA.
别名Tyro12, RP38, MGC133349, MERTK, MER, c-mer, c-Eyk
Ig Type
Mouse IgG2b
克隆号
7Y17
交叉反应
Human
应用
ELISA
推荐剂量
ELISA: 1:1000-1:2000
抗体种类
Monoclonal
宿主来源Mouse
构建方式This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human MERTK/Mer (rh MERTK/Mer; TMPY-04330; NP_006334.2; Met1-Ala499). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
纯化方式Protein A
性状Liquid
缓冲液0.2 μm filtered solution in PBS
研究背景Proto-oncogene tyrosine-protein kinase MER (MERTK) is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. MERTK is localized in the membrane and is no expressed in normal B- and T-lymphocytes but is expressed in numerous neoplastic B- and T-cell lines. This protein is highly expressed in the testis, ovary, prostate, lung, and kidney, with lower expression in the spleen, small intestine, colon, and liver. MERTK regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization, and engulfment. MERTK plays also an important role in the inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces the production of suppressors of cytokine signaling SOCS1 and SOCS3. Defects in MERTK are the cause of retinitis pigmentosa type 38.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Recombinant Protein: Human MERTK/Mer Protein (TMPY-04330)
抗原种属
Human
研究领域
Receptor Tyrosine Kinases (RTKs)
存储&运输
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
运输方式Shipping with blue ice.

计算器

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关键词

RP-38RP 38MGC-133349MGC 133349

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