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顶部生物活性储存和溶解信息计算器

Anti-IFNGR2 Antibody (8A302)

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产品编号 TMAY-03393

别名 interferon γ receptor 2 (interferon γ transducer 1), interferon gamma receptor 2 (interferon gamma transducer 1), Ifgt, Ifgr2

Anti-IFNGR2 Antibody (8A302) 是一种 Rabbit 抗体，靶向 IFNGR2。Anti-IFNGR2 Antibody (8A302) 可用于 ELISA。

Anti-IFNGR2 Antibody (8A302)

Anti-IFNGR2 Antibody (8A302)

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产品编号 TMAY-03393 别名 interferon γ receptor 2 (interferon γ transducer 1), interferon gamma receptor 2 (interferon gamma transducer 1), Ifgt, Ifgr2

Anti-IFNGR2 Antibody (8A302) 是一种 Rabbit 抗体，靶向 IFNGR2。Anti-IFNGR2 Antibody (8A302) 可用于 ELISA。

规格价格库存数量
100 μL
¥ 2,284
5日内发货
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产品介绍

生物活性
产品描述
Anti-IFNGR2 Antibody (8A302) is a Rabbit antibody targeting IFNGR2. Anti-IFNGR2 Antibody (8A302) can be used in ELISA.
别名interferon γ receptor 2 (interferon γ transducer 1), interferon gamma receptor 2 (interferon gamma transducer 1), Ifgt, Ifgr2
Ig Type
Rabbit IgG
克隆号
8A302
交叉反应
Mouse
特异性
Mouse IFNGR2
No cross-reactivity in ELISA with
Mouse IFNGR1
Human IL10RB
应用ELISA
推荐剂量
ELISA: 1:5000-1:10000
抗体种类
Monoclonal
宿主来源Rabbit
构建方式This antibody was obtained from a rabbit immunized with purified, recombinant Mouse IFNGR2 (rM IFNGR2; TMPY-02122; NP_032364.1; Met1-Val243).
纯化方式Protein A
性状Liquid
缓冲液0.2 μm filtered solution in PBS
研究背景Interferon-gamma receptor beta chain (IFNgammaR2), also known as IFNGR2, belongs to the type II cytokine receptor family, whose deficiency is a cause of autosomal recessive mendelian susceptibility to mycobacterial disease (MSMD), also known as familial disseminated atypical mycobacterial infection. This accessory factor is an integral part of the IFN-gamma signal transduction pathway and is likely to interact with GAF, JAK1, and/or JAK2. IFNGR2 is a component of the IFNgamma receptor complex along with the IFNgammaR alpha chain (IFNGR1) and is a new Bax suppressor. The C-terminal fragment (cytoplasmic domain) of IFNgammaR2 is expressed in human cancer cell lines of megakaryocytic cancer (DAMI), breast cancer (MDA-MD-468), and prostate cancer (PC3 cells). The Th1 cytokine IFNgamma, acting through its heterodimeric receptors, IFNgammaR1 and IFNgammaR2, in the induction/proliferation of Th1 cells, might suppress the Th2 responses that may underlie atopic asthma. IFNGR2 has always been seen as a key mechanism for shielding T lymphocytes from the antiproliferative effects of the IFNgamma-signal transducer and activator of the transcription 1 (STAT1) pathway.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Recombinant Protein: Mouse IFNGR2 protein (TMPY-02122)
抗原种属
Mouse
存储&运输
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
运输方式Shipping with blue ice.

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关键词

interferon gamma transducer 1interferon gamma receptor 2

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