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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-HSD11B2 Polyclonal Antibody

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货号 TMAB-07313

Anti-HSD11B2 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 HSD11B2。Anti-HSD11B2 Polyclonal Antibody 可用于 WB,IHC-P,IHC-Fr,IF。

Anti-HSD11B2 Polyclonal Antibody

Anti-HSD11B2 Polyclonal Antibody

一键复制产品信息
Rating icon 还可以
货号 TMAB-07313

Anti-HSD11B2 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 HSD11B2。Anti-HSD11B2 Polyclonal Antibody 可用于 WB,IHC-P,IHC-Fr,IF。

规格价格库存数量
50 μL
¥ 1,175
5日内发货
100 μL
¥ 1,970
5日内发货
200 μL
¥ 2,785
5日内发货
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产品介绍

生物活性
产品描述
Anti-HSD11B2 Polyclonal Antibody is a Rabbit antibody targeting HSD11B2. Anti-HSD11B2 Polyclonal Antibody can be used in WB,IHC-P,IHC-Fr,IF.
Ig Type
IgG
反应种属
Human,Mouse,Rat (predicted:Dog,Horse)
应用WBIHC-PIHC-FrIF
推荐剂量
WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Microsome. Endoplasmic reticulum.
组织特异性Found in placenta, kidney, pancreas, prostate, ovary, small intestine and colon.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液Preservative: 0.02% Proclin300, Constituents: 1% BSA, 0.01M PBS, pH7.4.
浓度1mg/ml
研究背景There are at least two isozymes of the corticosteroid 11-beta-dehydrogenase, a microsomal enzyme complex responsible for the interconversion of cortisol and cortisone. The type I isozyme has both 11-beta-dehydrogenase (cortisol to cortisone) and 11-oxoreductase (cortisone to cortisol) activities. The type II isozyme, encoded by this gene, has only 11-beta-dehydrogenase activity. In aldosterone-selective epithelial tissues such as the kidney, the type II isozyme catalyzes the glucocorticoid cortisol to the inactive metabolite cortisone, thus preventing illicit activation of the mineralocorticoid receptor. In tissues that do not express the mineralocorticoid receptor, such as the placenta and testis, it protects cells from the growth-inhibiting and/or pro-apoptotic effects of cortisol, particularly during embryonic development. Mutations in this gene cause the syndrome of apparent mineralocorticoid excess and hypertension. [provided by RefSeq, Feb 2010]
抗原信息
免疫原
KLH conjugated synthetic peptide: human HSD11B2
抗原种属
Human
基因名称
HSD11B2
基因ID
3291
蛋白名称
Corticosteroid 11-beta-dehydrogenase isozyme 2
Uniprot ID
P80365
功能
Catalyzes the conversion of cortisol to the inactive metabolite cortisone. Modulates intracellular glucocorticoid levels, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids.
化学信息
分子量Theoretical: 45 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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