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Anti-FOXO3 Antibody (6R502)
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产品编号 TMAC-01551
别名 MGC31925, MGC12739, FOXO3A, FOX O3A, Forkhead in rhabdomyosarcoma-like 1, Forkhead homolog (rhabdomyosarcoma) like 1, Forkhead Drosophila homolog of in rhabdomyosarcoma like 1, Forkhead box O3A, Forkhead box O3, Forkhead (Drosophila) homolog (rhabdomyosarcoma) like 1, FKHRL1P2, FKHRL1, FKHRL 1, FKHR2, DKFZp781A0677, AF6q21
Anti-FOXO3 Antibody (6R502) 是一种 Rabbit 抗体，靶向 FOXO3。Anti-FOXO3 Antibody (6R502) 可用于 WB,ICC/IF。
Anti-FOXO3 Antibody (6R502)
Anti-FOXO3 Antibody (6R502)
还可以产品编号 TMAC-01551 别名 MGC31925, MGC12739, FOXO3A, FOX O3A, Forkhead in rhabdomyosarcoma-like 1, Forkhead homolog (rhabdomyosarcoma) like 1, Forkhead Drosophila homolog of in rhabdomyosarcoma like 1, Forkhead box O3A, Forkhead box O3, Forkhead (Drosophila) homolog (rhabdomyosarcoma) like 1, FKHRL1P2, FKHRL1, FKHRL 1, FKHR2, DKFZp781A0677, AF6q21
Anti-FOXO3 Antibody (6R502) 是一种 Rabbit 抗体，靶向 FOXO3。Anti-FOXO3 Antibody (6R502) 可用于 WB,ICC/IF。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,490 | 5日内发货 | |
| 100 μL | ¥ 2,490 | 5日内发货 |
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| 产品描述 | Anti-FOXO3 Antibody (6R502) is a Rabbit antibody targeting FOXO3. Anti-FOXO3 Antibody (6R502) can be used in WB,ICC/IF. |
| 别名 | MGC31925, MGC12739, FOXO3A, FOX O3A, Forkhead in rhabdomyosarcoma-like 1, Forkhead homolog (rhabdomyosarcoma) like 1, Forkhead Drosophila homolog of in rhabdomyosarcoma like 1, Forkhead box O3A, Forkhead box O3, Forkhead (Drosophila) homolog (rhabdomyosarcoma) like 1, FKHRL1P2, FKHRL1, FKHRL 1, FKHR2, DKFZp781A0677, AF6q21 |
| Ig Type | IgG |
| 交叉反应 | Human |
| 验证活性 | 1. Western blot analysis of FOXO3A on different lysates using anti- FOXO3A antibody at 1/1,000 dilution. Positive control: Lane 1: NIH/3T3, Lane 2: PC-12, Lane 3: MCF-7. 2. ICC staining FOXO3A in Hela cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 3. ICC staining FOXO3A in MCF-7 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 4. ICC staining FOXO3A in SW480 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. |
| 应用 | |
| 推荐剂量 | WB: 1:1000-5000; ICC/IF: 1:50-200 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | Recombinant Antibody |
| 纯化方式 | ProA affinity purified |
| 性状 | Liquid |
| 缓冲液 | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| 研究背景 | FKHRL1 (forkhead in rhabdomyosarcoma-like 1), also known as FOXO3 (forkheadbox O3) or FOXO3A, is a 673 amino acid transcriptional activator thatbelongs to the FKHR subfamily of forkhead transcription factors. Transcriptional activation of FKHR proteins is regulated by the serine/threonine kinase Akt1, which phosphorylates FKHRL1 at Threonine 32 and Serine 253. Phosphorylation by Akt1 negatively regulates FKHRL1 by promoting its export from the nucleus. Phosphorylated FKHRL1 associates with 14-3-3 proteins and this complex is retained in the cytoplasm. Growth factor withdrawal stimulates FKHRL1 dephosphorylation and nuclear translocation, leading to FKHR-induced gene-specific transcriptional activation. Within the nucleus, dephosphorylated FKHRL1 triggers apoptosis by inducing the expression of genes that are critical for cell death. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Protein |
| Uniprot ID |
| 分子量 | Theoretical: 71 kDa. |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
计算器
比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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