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Anti-FGFR3 Antibody (6N712)
还可以产品编号 TMAY-03075
Anti-FGFR3 Antibody (6N712) 是一种 Rabbit 抗体，靶向 FGFR3。Anti-FGFR3 Antibody (6N712) 可用于 ELISA(Cap)。
Anti-FGFR3 Antibody (6N712)
Anti-FGFR3 Antibody (6N712)
还可以产品编号 TMAY-03075
Anti-FGFR3 Antibody (6N712) 是一种 Rabbit 抗体，靶向 FGFR3。Anti-FGFR3 Antibody (6N712) 可用于 ELISA(Cap)。
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偶联与修饰
抗原信息
| 产品描述 | Anti-FGFR3 Antibody (6N712) is a Rabbit antibody targeting FGFR3. Anti-FGFR3 Antibody (6N712) can be used in ELISA(Cap). |
| Ig Type | Monoclonal Rabbit IgG |
| 克隆号 | 6N712 |
| 交叉反应 | Mouse |
| 应用 | ELISA(Cap) |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | This antibody was obtained from a rabbit immunized with purified, recombinant Mouse FGFR3 / CD333 (rM FGFR3 / CD333; TMPY-01208; NP_032036.2; Met1-Tyr367). |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | FGFR3, also known as CD333, is a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. FGFRs are transmembrane catalytic receptors that have intracellular tyrosine kinase activity. Mutations in FGFR genes are the cause of several human developmental disorders characterized by skeletal abnormalities such as achondroplasia, and upregulation of FGFR expression may lead to cell transformation and cancer. FGFR3, a full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of FGFR3 interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. FGFR3 binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in FGFR3 gene lead to craniosynostosis and multiple types of skeletal dysplasia. Three alternatively spliced transcript variants that encode different protein isoforms have been described. CD333 is the receptor for acidic and basic fibroblast growth factors.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Mouse FGFR3 / CD333 Protein (TMPY-01208) |
| 抗原种属 | Mouse |
| 研究领域 | Receptor Tyrosine Kinases (RTKs), Cancer Drug Targets |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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