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Anti-ER alpha Antibody (7N404)
还可以产品编号 TMAY-00139
Anti-ER alpha Antibody (7N404) 是一种 Rabbit 抗体，靶向 ER alpha。Anti-ER alpha Antibody (7N404) 可用于 WB。
Anti-ER alpha Antibody (7N404)
Anti-ER alpha Antibody (7N404)
还可以产品编号 TMAY-00139
Anti-ER alpha Antibody (7N404) 是一种 Rabbit 抗体，靶向 ER alpha。Anti-ER alpha Antibody (7N404) 可用于 WB。
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产品介绍
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偶联与修饰
抗原信息
| 产品描述 | Anti-ER alpha Antibody (7N404) is a Rabbit antibody targeting ER alpha. Anti-ER alpha Antibody (7N404) can be used in WB. |
| Ig Type | Monoclonal Rabbit IgG |
| 克隆号 | 7N404 |
| 交叉反应 | Human |
| 验证活性 | Anti-ER alpha/ESR1 rabbit monoclonal antibody at 1:500 dilution. -Lane A: MCF7 Whole Cell Lysate. -Lane B: HeLa Whole Cell Lysate. -Lane C: Molt4 Whole Cell Lysate. -Lane D: Raji Whole Cell lysate. -Lysates/proteins at 30 μg per lane. -Secondary -Goat Anti-Rabbit IgG H&L (Dylight800) at 1/10000 dilution. -Developed using the Odyssey technique. -Performed under reducing conditions. -Predicted band size:66 kDa. -Observed band size:79 kDa |
| 应用 | WB |
| 推荐剂量 | WB: 1:500-1:2000 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | This antibody was obtained from a rabbit immunized with a synthetic peptide corresponding to the center region of the Human ER alpha/ESR1. The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | An ESR1 gene mutation, which encodes for the estrogen receptor (ER) protein, is one of the potential mechanisms of therapy resistance. The ESR1 mutations result in conformational changes in the ER leading to subsequent estrogen-independent transcriptional activity. The mutations within the estrogen receptor (ER) gene, ESR1, frequently occur in metastatic breast cancer and influence response to hormone therapy. Estrogen receptor alpha (ERalpha) is one of the estrogen hormone-activated transcription factors, which regulates a large number of genes and is involved in the mammary gland development. Expression of ERalpha is considered to be a good indicator for endocrine therapy and breast cancer survival. Loss of ERalpha in breast cancer patients indicates invasiveness and poor prognosis. ESR1 as a direct target of miR-301a-3p and suggest that miR-301a-3p likely contributes to development of estrogen independence, which leads to a more invasive phenotype of breast cancer. Polymorphisms of the estrogen receptor gene alpha (ESR1) are consistently been associated with bone mineral density (BMD) and fracture. |
| 偶联 | Unconjugated |
| 免疫原 | A synthetic peptide corresponding to the center region of the Human ER alpha/ESR1 |
| 抗原种属 | Human |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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