购物车
  • 全部删除
  • TargetMol
    您的购物车当前为空
前往下单页继续购物
顶部生物活性储存和溶解信息计算器

Anti-CYP3A4 Antibody (2B571)

Rating icon 还可以
Anti-CYP3A4 Antibody (2B571)
产品编号 TMAH-00329
别名 sulfoxide-forming, Quinine 3-monooxygenase, Nifedipine oxidase, Cytochrome P450-PCN1, Cytochrome P450 NF-25, Cytochrome P450 HLp, Cytochrome P450 3A4, Cytochrome P450 3A3, CYPIIIA4, CYPIIIA3, CYP3A3, Cholesterol 25-hydroxylase, Albendazole sulfoxidase, Albendazole monooxygenase, 1,8-cineole 2-exo-monooxygenase, 1,4-cineole 2-exo-monooxygenase

Anti-CYP3A4 Antibody (2B571) 是一种抗体，靶向 CYP3A4。Anti-CYP3A4 Antibody (2B571) 可用于 ELISA, IHC。

Anti-CYP3A4 Antibody (2B571)

Anti-CYP3A4 Antibody (2B571)

Rating icon 还可以
Anti-CYP3A4 Antibody (2B571)
产品编号 TMAH-00329 别名 sulfoxide-forming, Quinine 3-monooxygenase, Nifedipine oxidase, Cytochrome P450-PCN1, Cytochrome P450 NF-25, Cytochrome P450 HLp, Cytochrome P450 3A4, Cytochrome P450 3A3, CYPIIIA4, CYPIIIA3, CYP3A3, Cholesterol 25-hydroxylase, Albendazole sulfoxidase, Albendazole monooxygenase, 1,8-cineole 2-exo-monooxygenase, 1,4-cineole 2-exo-monooxygenase

Anti-CYP3A4 Antibody (2B571) 是一种抗体，靶向 CYP3A4。Anti-CYP3A4 Antibody (2B571) 可用于 ELISA, IHC。

规格价格库存数量
50 μL
¥ 1,315
5日内发货
100 μL
¥ 2,180
5日内发货
大包装 & 定制
加入购物车
TargetMol 的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。
实验操作小课堂
常见问题解答
查看更多
联系我们获取更多批次信息
资源下载
产品操作手册

产品介绍

生物活性
产品描述
Anti-CYP3A4 Antibody (2B571) is an antibody targeting CYP3A4. Anti-CYP3A4 Antibody (2B571) can be used in ELISA, IHC.
别名sulfoxide-forming, Quinine 3-monooxygenase, Nifedipine oxidase, Cytochrome P450-PCN1, Cytochrome P450 NF-25, Cytochrome P450 HLp, Cytochrome P450 3A4, Cytochrome P450 3A3, CYPIIIA4, CYPIIIA3, CYP3A3, Cholesterol 25-hydroxylase, Albendazole sulfoxidase, Albendazole monooxygenase, 1,8-cineole 2-exo-monooxygenase, 1,4-cineole 2-exo-monooxygenase
Ig Type
Rabbit IgG
克隆号
2B571
交叉反应
Human
验证活性
1. IHC image of TMAH-00329 diluted at 1:100 and staining in paraffin-embedded human liver tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.
2. IHC image of TMAH-00329 diluted at 1:100 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.
应用
ELISA
IHC
推荐剂量
IHC:1:50-1:200.
抗体种类
Monoclonal
亚细胞定位Endoplasmic reticulum membrane; Single-pass membrane protein. Microsome membrane; Single-pass membrane protein.
组织特异性Expressed in prostate and liver. According to some authors, it is not expressed in brain. According to others, weak levels of expression are measured in some brain locations. Also expressed in epithelium of the small intestine and large intestine, bile du
构建方式Recombinant Antibody
纯化方式Affinity-chromatography
性状Liquid
缓冲液Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
研究背景A cytochrome P450 monooxygenase involved in the metabolism of sterols, steroid hormones, retinoids and fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E2, as well as D-ring hydroxylated E1 and E2 at the C-16 position. Plays a role in the metabolism of androgens, particularly in oxidative deactivation of testosterone. Metabolizes testosterone to less biologically active 2beta- and 6beta-hydroxytestosterones. Contributes to the formation of hydroxycholesterols (oxysterols), particularly A-ring hydroxylated cholesterol at the C-4beta position, and side chain hydroxylated cholesterol at the C-25 position, likely contributing to cholesterol degradation and bile acid biosynthesis. Catalyzes bisallylic hydroxylation of polyunsaturated fatty acids (PUFA). Catalyzes the epoxidation of double bonds of PUFA with a preference for the last double bond. Metabolizes endocannabinoid arachidonoylethanolamide (anandamide) to 8,9-, 11,12-, and 14,15-epoxyeicosatrienoic acid ethanolamides (EpETrE-EAs), potentially modulating endocannabinoid system signaling. Plays a role in the metabolism of retinoids. Displays high catalytic activity for oxidation of all-trans-retinol to all-trans-retinal, a rate-limiting step for the biosynthesis of all-trans-retinoic acid (atRA). Further metabolizes atRA toward 4-hydroxyretinoate and may play a role in hepatic atRA clearance. Responsible for oxidative metabolism of xenobiotics. Acts as a 2-exo-monooxygenase for plant lipid 1,8-cineole (eucalyptol). Metabolizes the majority of the administered drugs. Catalyzes sulfoxidation of the anthelmintics albendazole and fenbendazole. Hydroxylates antimalarial drug quinine. Acts as a 1,4-cineole 2-exo-monooxygenase. Also involved in vitamin D catabolism and calcium homeostasis. Catalyzes the inactivation of the active hormone calcitriol (1-alpha,25-dihydroxyvitamin D(3)).
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
A synthetic peptide: Human Cytochrome P450 3A4
抗原种属
Human
基因名称
CYP3A4
基因ID
1576
Uniprot ID
P08684
研究领域
Cancer, Cardiovascular, Metabolism, Signal transduction
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

计算器

  • 稀释 计算器

评论列表

4个月前
5.0
Rating icon 很棒

评论内容

233
Related Tags: buy Anti-CYP3A4 Antibody (2B571) | purchase Anti-CYP3A4 Antibody (2B571) | Anti-CYP3A4 Antibody (2B571) cost | order Anti-CYP3A4 Antibody (2B571)