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Anti-Contactin 1 Antibody (3L885)
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产品编号 TMAY-00732
别名 usl, F3cam, contactin 1, CNTN, AW495098
Anti-Contactin 1 Antibody (3L885) 是一种 Mouse 抗体，靶向 Contactin 1。Anti-Contactin 1 Antibody (3L885) 可用于 ELISA。
Anti-Contactin 1 Antibody (3L885)
Anti-Contactin 1 Antibody (3L885)
还可以产品编号 TMAY-00732 别名 usl, F3cam, contactin 1, CNTN, AW495098
Anti-Contactin 1 Antibody (3L885) 是一种 Mouse 抗体，靶向 Contactin 1。Anti-Contactin 1 Antibody (3L885) 可用于 ELISA。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 100 μL | ¥ 1,694 | 5日内发货 |
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抗原信息
| 产品描述 | Anti-Contactin 1 Antibody (3L885) is a Mouse antibody targeting Contactin 1. Anti-Contactin 1 Antibody (3L885) can be used in ELISA. |
| 别名 | usl, F3cam, contactin 1, CNTN, AW495098 |
| Ig Type | Mouse IgG2b |
| 克隆号 | 3L885 |
| 交叉反应 | Human |
| 应用 | |
| 推荐剂量 | ELISA: 1:1000-1:2000 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CNTN1 (rhCNTN1; TMPY-00720; Met1-Ser993; NP_001834.2). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | Contactins are a subgroup of molecules belonging to the immunoglobulin superfamily that are expressed exclusively in the nervous system. The subgroup consists of six members: Contactin-1, Contactin-2 (TAG-1), Contactin-3 (BIG-1), BIG-2, Contactin-5 (NB-2) and NB-3. Since their identification in the late 1980s, Contactin-1 and Contactin-2 have been studied extensively. Axonal expression and the neurite extension activity of Contactin-1 and Contactin-2 attracted researchers to study the function of these molecules in axon guidance during development. Contactin-1 and Contactin-2 have come to be known as the principal molecules in the function and maintenance of myelinated neurons. In contrast, the function of the other four members of this subgroup remained unknown until recently. Contactin-1 is a cell surface adhesion molecule that is normally expressed by neurons and oligodendrocytes. Particularly high levels of Contactin-1 are present during brain development. Contactin-1 and Contactin-2 are differentially expressed in a number of neuronal tissues during development, and they interact with several ligands including Nr-CAM, L1, NCAM, neurocan, phosphacan, and tenascin. As a cell adhesion molecule, Contactin-1 plays a role in the formation of axon connections in the developing nervous system. It was demonstrated that Contactin-1 participates in signal pathways via its association with Contactin-associated protein (CNTNAP1), receptor protein tyrosine phosphatase beta (RPTPb) and NOTCH1. Contactin-1 is also involved in paranodal axo-glial junction formation and oligodendrocytes generation. Furthermore, studies indicated that Contactin-1 functions importantly in the invasion and metastasis of lung adenocarcinoma cells. Contactin-1 may also significantly influence the functional expression and distribution of Na+channels in neurons. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Protein: Human CNTN1 protein (TMPY-00720) |
| 抗原种属 | Human |
| 研究领域 | Notch Pathway |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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