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Anti-CIB2 Antibody (1S602)
还可以产品编号 TMAY-02391
Anti-CIB2 Antibody (1S602) 是一种 Mouse 抗体，靶向 CIB2。Anti-CIB2 Antibody (1S602) 可用于 ELISA(Cap)。
Anti-CIB2 Antibody (1S602)
Anti-CIB2 Antibody (1S602)
还可以产品编号 TMAY-02391
Anti-CIB2 Antibody (1S602) 是一种 Mouse 抗体，靶向 CIB2。Anti-CIB2 Antibody (1S602) 可用于 ELISA(Cap)。
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产品介绍
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偶联与修饰
抗原信息
| 产品描述 | Anti-CIB2 Antibody (1S602) is a Mouse antibody targeting CIB2. Anti-CIB2 Antibody (1S602) can be used in ELISA(Cap). |
| Ig Type | Monoclonal Mouse IgG2a |
| 克隆号 | 1S602 |
| 交叉反应 | Human |
| 应用 | ELISA(Cap) |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CIB2 (rh CIB2; TMPY-02289; O75838; Met1-Ile187). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | Calcium and integrin-binding protein 2 (CIB2) belongs to a protein family with four known members, CIB1 through CIB4, which are characterized by multiple calcium-binding EF-hand domains. Sensorineural hearing loss is genetically heterogeneous. The mutations in CIB2, which encodes a calcium- and integrin-binding protein, are associated with nonsyndromic deafness (DFNB48) and Usher syndrome type 1J (USH1J). Furthermore, in zebrafish and Drosophila melanogaster, CIB2 is essential for the function and proper development of hair cells and retinal photoreceptor cells. We also show that CIB2 is a new member of the vertebrate Usher interactome. Variants in CIB2 can underlie either Usher syndrome type I (USH1J) or nonsyndromic hearing impairment (NSHI) (DFNB48). CIB2 is widely expressed in various human and animal tissues, mainly in skeletal muscle, nervous tissue, inner ear, and retina. The CIB2 protein is responsible for maintaining Ca(2+) homeostasis in cells and interacting with integrins-transmembrane receptors essential for cell adhesion, migration, and activation of signaling pathways. Calcium signaling pathway is crucial for signal transduction in the inner ear, and integrins regulate hair cell differentiation and maturation of the stereocilia. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Human CIB2 Protein (TMPY-02289) |
| 抗原种属 | Human |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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