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顶部生物活性储存和溶解信息计算器

Anti-CD16a Antibody (3I481)

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产品编号 TMAY-00739

别名 Fc fragment of IgG, low affinity IIIa, receptor (CD16a)

Anti-CD16a Antibody (3I481) 是一种 Mouse 抗体，靶向 CD16a。Anti-CD16a Antibody (3I481) 可用于 IHC-P。

Anti-CD16a Antibody (3I481)

Anti-CD16a Antibody (3I481)

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Rating icon 还可以
产品编号 TMAY-00739 别名 Fc fragment of IgG, low affinity IIIa, receptor (CD16a)

Anti-CD16a Antibody (3I481) 是一种 Mouse 抗体，靶向 CD16a。Anti-CD16a Antibody (3I481) 可用于 IHC-P。

规格价格库存数量
100 μL
¥ 1,694
5日内发货
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产品介绍

生物活性
产品描述
Anti-CD16a Antibody (3I481) is a Mouse antibody targeting CD16a. Anti-CD16a Antibody (3I481) can be used in IHC-P.
别名Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
Ig Type
Mouse IgG1
克隆号
3I481
交叉反应
Human
特异性
Human CD16a/FCGR3A/Fc gamma RIIIA
Has cross-reactivity in ELISA with
Human CD16b
No cross-reactivity in ELISA with
Human CD32a
Human CD32b
Human CD64
验证活性
1. Immunochemical staining of human CD16a in human spleen with mouse monoclonal antibody (1:500, formalin-fixed paraffin embedded sections).
2. Immunochemical staining of human CD16a in human lung with mouse monoclonal antibody (1:500, formalin-fixed paraffin embedded sections).
3. Immunochemical staining of human CD16a in human liver with mouse monoclonal antibody (1:500, formalin-fixed paraffin embedded sections).
应用IHC-P
推荐剂量
IHC-P: 1:250-1:1000
抗体种类
Monoclonal
宿主来源Mouse
构建方式This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD16a / FCGR3A (rh CD16a / FCGR3A; TMPY-00763; P08637-1; Met1-Gln208,176F). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
纯化方式Protein A
性状Liquid
缓冲液0.2 μm filtered solution in PBS
研究背景The Fc receptor with low affinity for IgG (FCGR3, or CD16) is encoded by 2 nearly identical genes, FCGR3A and FCGR3B, resulting in tissue-specific expression of alternative membrane-anchored isoforms. FCGR3A, it is also known as CD16a, encodes a transmembrane protein expressed on activated monocytes/macrophages, natural killer (NK) cells, and a subset of T cells. CD16a / FCGR3A is a receptor expressed on NK cells that facilitates antibody dependent cellular cytotoxicity (ADCC) by binding to the Fc portion of various antibodies. CD16a / FCGR3A also has a broader function. CD16a / FCGR3A is directly involved in the lysis of some virus-infected cells and tumor cells by NK cells, independent of antibody binding. Cross-linking of CD16a / FCGR3A on NK cells resulted in increased intracellular Ca2+ levels and a cascade of biochemical events similar to those activated by the T cell receptor. CD16a / FCGR3A on human NK cells is a lysis receptor that mediates the direct killing of some virus infected and tumor cells, independent of antibody ligation.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Recombinant Protein: Human CD16a / FCGR3A protein (TMPY-00763)
抗原种属
Human
研究领域
Fc Receptors, Cancer Drug Targets, ITIM/ITAM Immunoreceptors and Related Molecules
存储&运输
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
运输方式Shipping with blue ice.

计算器

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关键词

Fc fragment of IgG, low affinity IIIa, receptorCD16a

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4个月前
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