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Anti-CD16a Antibody (3I481)
还可以产品编号 TMAY-00739
Anti-CD16a Antibody (3I481) 是一种 Mouse 抗体，靶向 CD16a。Anti-CD16a Antibody (3I481) 可用于 IHC-P。
Anti-CD16a Antibody (3I481)
Anti-CD16a Antibody (3I481)
还可以产品编号 TMAY-00739
Anti-CD16a Antibody (3I481) 是一种 Mouse 抗体，靶向 CD16a。Anti-CD16a Antibody (3I481) 可用于 IHC-P。
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抗原信息
| 产品描述 | Anti-CD16a Antibody (3I481) is a Mouse antibody targeting CD16a. Anti-CD16a Antibody (3I481) can be used in IHC-P. |
| Ig Type | Monoclonal Mouse IgG1 |
| 克隆号 | 3I481 |
| 交叉反应 | Human |
| 验证活性 | 1. Immunochemical staining of human CD16a in human spleen with mouse monoclonal antibody (1:500, formalin-fixed paraffin embedded sections). 2. Immunochemical staining of human CD16a in human lung with mouse monoclonal antibody (1:500, formalin-fixed paraffin embedded sections). 3. Immunochemical staining of human CD16a in human liver with mouse monoclonal antibody (1:500, formalin-fixed paraffin embedded sections). |
| 应用 | IHC-P |
| 推荐剂量 | IHC-P: 1:250-1:1000 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD16a / FCGR3A (rh CD16a / FCGR3A; TMPY-00763; P08637-1; Met1-Gln208,176F). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | The Fc receptor with low affinity for IgG (FCGR3, or CD16) is encoded by 2 nearly identical genes, FCGR3A and FCGR3B, resulting in tissue-specific expression of alternative membrane-anchored isoforms. FCGR3A, it is also known as CD16a, encodes a transmembrane protein expressed on activated monocytes/macrophages, natural killer (NK) cells, and a subset of T cells. CD16a / FCGR3A is a receptor expressed on NK cells that facilitates antibody dependent cellular cytotoxicity (ADCC) by binding to the Fc portion of various antibodies. CD16a / FCGR3A also has a broader function. CD16a / FCGR3A is directly involved in the lysis of some virus-infected cells and tumor cells by NK cells, independent of antibody binding. Cross-linking of CD16a / FCGR3A on NK cells resulted in increased intracellular Ca2+ levels and a cascade of biochemical events similar to those activated by the T cell receptor. CD16a / FCGR3A on human NK cells is a lysis receptor that mediates the direct killing of some virus infected and tumor cells, independent of antibody ligation. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Human CD16a / FCGR3A protein (TMPY-00763) |
| 抗原种属 | Human |
| 研究领域 | Fc Receptors, Cancer Drug Targets, ITIM/ITAM Immunoreceptors and Related Molecules |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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