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Anti-Cadherin 16/CDH16 Antibody (9V223)
还可以产品编号 TMAY-01326
Anti-Cadherin 16/CDH16 Antibody (9V223) 是一种 Mouse 抗体，靶向 Cadherin 16/CDH16。Anti-Cadherin 16/CDH16 Antibody (9V223) 可用于 IHC-P。
Anti-Cadherin 16/CDH16 Antibody (9V223)
Anti-Cadherin 16/CDH16 Antibody (9V223)
还可以产品编号 TMAY-01326
Anti-Cadherin 16/CDH16 Antibody (9V223) 是一种 Mouse 抗体，靶向 Cadherin 16/CDH16。Anti-Cadherin 16/CDH16 Antibody (9V223) 可用于 IHC-P。
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| 产品描述 | Anti-Cadherin 16/CDH16 Antibody (9V223) is a Mouse antibody targeting Cadherin 16/CDH16. Anti-Cadherin 16/CDH16 Antibody (9V223) can be used in IHC-P. |
| Ig Type | Monoclonal Mouse IgG1 |
| 克隆号 | 9V223 |
| 交叉反应 | Human |
| 验证活性 | Immunochemical staining of human CDH16 in human kidney with mouse monoclonal antibody (1:60, formalin-fixed paraffin embedded sections). |
| 应用 | IHC-P |
| 推荐剂量 | IHC-P: 1:50-1:200 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human KSP-Cadherin / Cadherin-16 (rh KSP-Cadherin / Cadherin-16; TMPY-01763; NP_004053.1; Met1-Ala786). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | KSP-Cadherin/Cadherin-16 is a member of the cadherin superfamily, calcium-dependent, membrane-associated glycoproteins. The protein consists of an extracellular domain containing 6 cadherin domains, a transmembrane region and a truncated cytoplasmic domain but lacks the prosequence and tripeptide HAV adhesion recognition sequence typical of most classical cadherins. Expression is exclusively in kidney, where the protein functions as the principal mediator of homotypic cellular recognition, playing a role in the morphogenic direction of tissue development. KSP-Cadherin/Cadherin-16 can be detected at later stages of tubulogenesis during human renal development and in the distal tubules of adult kidneys, no expression was found by immunohistochemistry or Western blot analysis in RCC tumour tissues and several RCC cell lines. However, despite the lack of protein expression, mRNA synthesis of KSP-Cadherin/Cadherin-16 could be detected by reverse transcriptase-polymerase chain reaction analysis in all RCC tissues and most of the RCC cell lines studied, although at a reduced level. The loss of KSP-Cadherin/Cadherin-16 protein was only observed in the malignant part of the tumour kidneys, whereas in the normal part of the affected kidneys KSP-Cadherin/Cadherin-16 expression was clearly detected. These results indicate a downregulation of Ksp-cadherin in RCC and suggest a role for this cell adhesion molecule in tumour suppression. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Human KSP-Cadherin / Cadherin-16 Protein (TMPY-01763) |
| 抗原种属 | Human |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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