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Anti-BST2 Antibody (2B626)
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产品编号 TMAY-02577
别名 GREG, DAMP-1, CD317, C87040, Bst-2, bone marrow stromal cell antigen 2, 2310015I10Rik
Anti-BST2 Antibody (2B626) 是一种 Mouse 抗体，靶向 BST2。Anti-BST2 Antibody (2B626) 可用于 IHC-P。
Anti-BST2 Antibody (2B626)
Anti-BST2 Antibody (2B626)
还可以产品编号 TMAY-02577 别名 GREG, DAMP-1, CD317, C87040, Bst-2, bone marrow stromal cell antigen 2, 2310015I10Rik
Anti-BST2 Antibody (2B626) 是一种 Mouse 抗体，靶向 BST2。Anti-BST2 Antibody (2B626) 可用于 IHC-P。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 100 μL | ¥ 1,684 | 5日内发货 |
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-BST2 Antibody (2B626) is a Mouse antibody targeting BST2. Anti-BST2 Antibody (2B626) can be used in IHC-P. |
| 别名 | GREG, DAMP-1, CD317, C87040, Bst-2, bone marrow stromal cell antigen 2, 2310015I10Rik |
| Ig Type | Mouse IgG1 |
| 克隆号 | 2B626 |
| 交叉反应 | Human |
| 验证活性 | Immunochemical staining of human BST2 in human liver with mouse monoclonal antibody (1:60, formalin-fixed paraffin embedded sections). |
| 应用 | |
| 推荐剂量 | IHC-P: 1:50-1:200 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human BST2 (rh BST2; TMPY-03235; Q10589; Asn49-Ser160). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | BST2 was frequently overexpressed in GC tissues compared with the adjacent non-tumorous tissues, and high BST2 expression was correlated with tumor stage and lymphatic metastasis. Furthermore, in vitro experiments demonstrated that knockdown of BST2 by siRNA inhibited cell proliferation, induced apoptosis and repressed cell motility in GC cells. In addition, the pro-tumor function of BST2 in GC was mediated partly through the NF-κB signaling. BST2 possesses the oncogenic potential in GC by regulating the proliferation, apoptosis, and migratory ability of GC cells, thereby BST2 could be a potential therapeutic target for the treatment of GC. IFN (interferon)-induced BST2 recruits the E3 ubiquitin ligase MARCH8 to catalyze the K27-linked ubiquitination of MAVS for CALCOCO2-directed autophagic degradation, hence inhibiting DDX58-mediated type I interferon signaling through a negative feedback loop. BST2 is a host protein with dual functions in response to viral infections: it traps newly assembled enveloped virions at the plasma membrane in infected cells, and it induces NF-κB activity, especially in the context of retroviral assembly. BST2 may induce or amplify proinflammatory signaling during Ebola virus infection, potentially contributing to the dysregulated cytokine response that is a hallmark of Ebola virus disease. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Protein: Human BST2 Protein (TMPY-03235) |
| 抗原种属 | Human |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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