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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-BRMS1 Polyclonal Antibody

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货号 TMAB-03221

Anti-BRMS1 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 BRMS1。Anti-BRMS1 Polyclonal Antibody 可用于 ICC/IF。

Anti-BRMS1 Polyclonal Antibody

Anti-BRMS1 Polyclonal Antibody

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货号 TMAB-03221

Anti-BRMS1 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 BRMS1。Anti-BRMS1 Polyclonal Antibody 可用于 ICC/IF。

规格价格库存数量
50 μL
¥ 1,170
5日内发货
100 μL
¥ 1,970
5日内发货
200 μL
¥ 2,790
5日内发货
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产品介绍

生物活性
产品描述
Anti-BRMS1 Polyclonal Antibody is a Rabbit antibody targeting BRMS1. Anti-BRMS1 Polyclonal Antibody can be used in ICC/IF.
Ig Type
IgG
反应种属
Human (predicted:Mouse,Rat)
应用ICC/IF
推荐剂量
ICC/IF: 1:50-200
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Nucleus. Cytoplasm. Predominantly nuclear.
组织特异性Expression levels are higher in term placentas than in early placentas. Low levels of expression observed in normal pregnancies and in molar pregnancies.
构建方式Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景Breast cancer metastasis-suppressor 1 (BRMS1) is 246 amino acid protein that acts as a mediator of metastasis suppression in several types of cancer including ovarian, lung, bladder, and murine mammary. BRMS1 mRNA is expressed in various tissues, including ovary, prostate, testis, and colon, but the protein is primarily detected in term placenta. BRMS1 suppresses metastasis without inhibiting tumorigenicity by modifying several metastasis-associated phenotypes. BRMS1 may participate in transcriptional regulation by binding to the mSin3/histone deacetylase complex. The expression of BRMS1 in certain cells increases connexin Cx43 expression and reduces connexin Cx32 expression. This produces a gap junction that increases intercellular communication, similar to those found in normal breast tissue. BRMS1 is stabilized by Hsp90 and may inhibit NF-ⅹB activity.
抗原信息
免疫原
KLH conjugated synthetic peptide: human BRMS-1
抗原种属
Human
基因名称
BRMS1
基因ID
25855
蛋白名称
Breast cancer metastasis-suppressor 1
Uniprot ID
Q9HCU9
功能
Transcriptional repressor. Down-regulates transcription activation by NF-kappa-B by promoting the deacetylation of RELA at 'Lys-310'. Promotes HDAC1 binding to promoter regions. Down-regulates expression of anti-apoptotic genes that are controlled by NF-kappa-B. Promotes apoptosis in cells that have inadequate adherence to a substrate, a process called anoikis, and may thereby inhibit metastasis. May be a mediator of metastasis suppression in breast carcinoma.
化学信息
分子量Theoretical: 28 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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