Anti-BID Antibody (1O729)

Name: Anti-BID Antibody (1O729)
Brand: TargetMol
SKU: TMAY-00868
Rating: 4.5 (1 reviews)

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产品编号 TMAY-00868

别名 BH3 interacting domain death agonist, AU022477, AI875481, 2700049M22Rik

Anti-BID Antibody (1O729) 是一种 Mouse 抗体，靶向 BID。Anti-BID Antibody (1O729) 可用于 WB,ELISA,ELISA(Det)。

Anti-BID Antibody (1O729)

还可以

产品编号 TMAY-00868 别名 BH3 interacting domain death agonist, AU022477, AI875481, 2700049M22Rik

Anti-BID Antibody (1O729) 是一种 Mouse 抗体，靶向 BID。Anti-BID Antibody (1O729) 可用于 WB,ELISA,ELISA(Det)。

规格	价格	库存	数量
20 μL	¥ 580	5日内发货
100 μL	¥ 1,694	5日内发货

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生物活性

产品描述	Anti-BID Antibody (1O729) is a Mouse antibody targeting BID. Anti-BID Antibody (1O729) can be used in WB,ELISA,ELISA(Det).
别名	BH3 interacting domain death agonist, AU022477, AI875481, 2700049M22Rik
Ig Type	Monoclonal Mouse IgG2a
克隆号	1O729
交叉反应	Human
验证活性	Anti-BID mouse monoclonal antibody at 1:500 dilution. -Lane A: Jurkat Whole Cell lysate. -Lysates/proteins at 30 μg per lane. -Secondary -Goat Anti-Mouse IgG H&L (Dylight800) at 1/15000 dilution. -Developed using the Odyssey technique. -Performed under reducing conditions. -Predicted band size:22 kDa. -Observed band size:22 kDa
应用	WB,ELISA,ELISA(Det)
推荐剂量	WB: 1:500-1:2000; ELISA: 1:1000-1:2000; ELISA(Det): 1:1000-1:10000
抗体种类	Monoclonal
宿主来源	Mouse
构建方式	This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human BID (rh BID; TMPY-02027; P55957-1; Met 1-Asp 195). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
纯化方式	Protein A
性状	Liquid
缓冲液	0.2 μm filtered solution in PBS
研究背景	The BH3 interacting domain death agonist (BID) is a pro-apoptotic member of the Bcl-2 protein family, which contains only the BH3 domain, and is required for its interaction with the Bcl-2 family proteins and for its pro-death activity. BID is important to cell death mediated by these proteases and thus is the sentinel to protease-mediated death signals. Recent studies further indicate that Bid may be more than just a killer molecule, it could be also involved in the maintenance of genomic stability by engaging at mitosis checkpoint. BID is an integrating key regulator of the intrinsic death pathway that amplifies caspase-dependent and caspase-independent execution of neuronal apoptosis. Therefore pharmacological inhibition of BID provides a promising therapeutic strategy in neurological diseases where programmed cell death is prominent. BID is activated by Caspase 8 in response to Fas/TNF-R1 death receptor activation. Activated BID is translocated to mitochondria and induces cytochrome c release, which in turn activates downstream caspases. BID action has been proposed to involve the mitochondrial re-location of its truncated form, tBid, to facilitate the release of apoptogenic proteins like cytochrome c.

偶联与修饰

偶联	Unconjugated
其他可选修饰符	HRP
可提供抗体种类	2

抗原信息

免疫原	Recombinant Human BID protein (TMPY-02027)
抗原种属	Human

存储&运输

储存方式	Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
运输方式	Shipping with blue ice.