Anti-AXL Antibody (4J472)

Name: Anti-AXL Antibody (4J472)
Brand: TargetMol
SKU: TMAY-00551
Rating: 4.5 (1 reviews)

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产品编号 TMAY-00551

Anti-AXL Antibody (4J472) 是一种 Mouse 抗体，靶向 AXL。Anti-AXL Antibody (4J472) 可用于 ELISA。

Anti-AXL Antibody (4J472)

还可以

产品编号 TMAY-00551

Anti-AXL Antibody (4J472) 是一种 Mouse 抗体，靶向 AXL。Anti-AXL Antibody (4J472) 可用于 ELISA。

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产品描述	Anti-AXL Antibody (4J472) is a Mouse antibody targeting AXL. Anti-AXL Antibody (4J472) can be used in ELISA.
Ig Type	Monoclonal Mouse IgG1
克隆号	4J472
交叉反应	Human
应用	ELISA
推荐剂量	ELISA: 1:1000-1:2000
抗体种类	Monoclonal
宿主来源	Mouse
构建方式	This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human AXL (rh AXL; TMPY-01601; AAB20305.1; Met 1-Pro 449). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
纯化方式	Protein A
性状	Liquid
缓冲液	0.2 μm filtered solution in PBS
研究背景	Axl receptor tyrosine kinase, together with Tyro3 and Mer, constitute the TAM family of receptor tyrosine kinases. In the nervous system, Axl and its ligand Growth-arrest-specific protein 6 (Gas6) are expressed on multiple cell types. Axl functions in dampening the immune response, regulating cytokine secretion, clearing apoptotic cells and debris, and maintaining cell survival. Axl is upregulated in various disease states, such as in the cuprizone toxicity-induced model of demyelination and in multiple sclerosis (MS) lesions, suggesting that it plays a role in disease pathogenesis. Axl expression correlates with poor prognosis in several cancers. Axl mediates multiple oncogenic phenotypes and activation of these RTKs constitutes a mechanism of chemoresistance in a variety of solid tumors. Axl contributes to cell survival, migration, invasion, metastasis and chemosensitivity justify further investigation of Axl as novel therapeutic targets in cancer. The receptor tyrosine kinase AXL is thought to play a role in metastasis. The soluble AXL receptor as a therapeutic candidate agent for treatment of metastatic ovarian cancer. GAS6/AXL targeting as an effective strategy for inhibition of metastatic tumor progression in vivo.

偶联与修饰

偶联	Unconjugated

抗原信息

免疫原	Recombinant Human AXL protein (TMPY-01601)
抗原种属	Human
研究领域	Receptor Tyrosine Kinases (RTKs)

存储&运输

储存方式	Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
运输方式	Shipping with blue ice.