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Anti-ARSA Antibody (6H122)
还可以产品编号 TMAY-00844
别名 TISP73, AW212749, AS-A, ASA, As-2, As2, arylsulfatase A
Anti-ARSA Antibody (6H122) 是一种 Rabbit 抗体，靶向 ARSA。Anti-ARSA Antibody (6H122) 可用于 WB。
Anti-ARSA Antibody (6H122)
Anti-ARSA Antibody (6H122)
还可以产品编号 TMAY-00844 别名 TISP73, AW212749, AS-A, ASA, As-2, As2, arylsulfatase A
Anti-ARSA Antibody (6H122) 是一种 Rabbit 抗体，靶向 ARSA。Anti-ARSA Antibody (6H122) 可用于 WB。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 100 μL | ¥ 2,294 | 5日内发货 |
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-ARSA Antibody (6H122) is a Rabbit antibody targeting ARSA. Anti-ARSA Antibody (6H122) can be used in WB. |
| 别名 | TISP73, AW212749, AS-A, ASA, As-2, As2, arylsulfatase A |
| Ig Type | Monoclonal Rabbit IgG |
| 克隆号 | 6H122 |
| 交叉反应 | Human |
| 验证活性 | Anti-ARSA rabbit monoclonal antibody at 1:500 dilution. -Lane A: HepG2 Whole Cell lysate. -Lysates/proteins at 30 μg per lane. -Secondary -Goat Anti-Rabbit IgG H&L (Dylight800) at 1/10000 dilution. -Developed using the Odyssey technique. -Performed under reducing conditions. -Predicted band size:54 kDa. -Observed band size:60 kDa |
| 应用 | WB |
| 推荐剂量 | WB: 1:500-1:2000 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | This antibody was obtained from a rabbit immunized with purified, recombinant Human Arylsulfatase A / ARSA (rh Arylsulfatase A / ARSA; TMPY-00669; P15289-1; Met 1-Ala 507). |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | Arylsulfatase A (ARSA) is synthesized as a 52KDa lysosomal enzyme. It is a member of the sulfatase family that is required for the lysosomal degradation of cerebroside-3-sulfate, a sphingolipid sulfate ester and a major constituent of the myelin sheet. Arylsulfatase A is activated by a required co- or posttranslational modification with the oxidation of cysteine to formylglycine. Metachromatic leukodystrophy (MLD) is a lysosomal storage disease in the central and peripheral nervous systems with severe and progressive neurological symptoms caused by the deficiency of Arylsulfatase A. Deficiency of this enzyme is also found in apparently healthy individuals, a condition for which the term pseudodeficiency is introduced. ARSA forms dimers after receiving three N-linked oligosaccharides in the endoplasmic reticulum, and then the dimers are transported to the Golgi where they receive mannose 6-phosphate recognition markers. And thus, ARSA is transported and delivered to dense lysosomes in a mannose 6-phosphate receptor-dependent manner. It has been shown that within the lysosomes, the ARSA dimers can oligomerize to an octamer in a pH-dependent manner. The ARSA deficiency leads to metachromatic leucodystrophy (MLD), a lysosomal storage disorder associated with severe and progressive demyelination in he central and peripheral nervous system. Additionally, the serum level of arylsulfatase A might be helpful in diagnosis of lung and central nervous system cancer. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Human Arylsulfatase A / ARSA protein (TMPY-00669) |
| 抗原种属 | Human |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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