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Anti-Aminoacylase 1 Antibody (1H430)
还可以产品编号 TMAY-00963
别名 HEL-S-5, aminoacylase 1, ACY1D, ACY-1
Anti-Aminoacylase 1 Antibody (1H430) 是一种 Rabbit 抗体，靶向 Aminoacylase 1。Anti-Aminoacylase 1 Antibody (1H430) 可用于 FCM,ICC/IF。
Anti-Aminoacylase 1 Antibody (1H430)
Anti-Aminoacylase 1 Antibody (1H430)
还可以产品编号 TMAY-00963 别名 HEL-S-5, aminoacylase 1, ACY1D, ACY-1
Anti-Aminoacylase 1 Antibody (1H430) 是一种 Rabbit 抗体，靶向 Aminoacylase 1。Anti-Aminoacylase 1 Antibody (1H430) 可用于 FCM,ICC/IF。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 100 μL | ¥ 2,289 | 5日内发货 |
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-Aminoacylase 1 Antibody (1H430) is a Rabbit antibody targeting Aminoacylase 1. Anti-Aminoacylase 1 Antibody (1H430) can be used in FCM,ICC/IF. |
| 别名 | HEL-S-5, aminoacylase 1, ACY1D, ACY-1 |
| Ig Type | Monoclonal Rabbit IgG |
| 克隆号 | 1H430 |
| 交叉反应 | Human |
| 验证活性 | 1. Immunofluorescence staining of Human ACY1 in Hela or SKBR3 cells. Cells were fixed with 4% PFA, permeabilzed with 1% Triton X-100 in PBS, blocked with 10% serum, and incubated with Rabbit anti-Human ACY1 monoclonal antibody (1:60). Then cells were stained with the Alexa Fluor® 488-conjugated Goat Anti-rabbit IgG secondary antibody (left panel, captured by laser confocal scanning microscope; right panel, captured by fluorescence microscope), countstained with DAPI (blue). Positive staining was localized to cytoplasm. 2. Flow cytometric analysis of Human ACY1 expression on HepG2 cells. The cells were treated according to manufacturer’s manual (BD Pharmingen™ Cat. No. 554714), stained with purified anti-Human ACY1, then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells. |
| 应用 | FCM,ICC/IF |
| 推荐剂量 | ICC-IF: 1:20-1:100; FCM: 1:25-1:100 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | This antibody was obtained from a rabbit immunized with purified, recombinant Human ACY1 / Aminoacylase-1 (rh ACY1 / Aminoacylase-1; TMPY-01058; NP_000657.1; Met1-Ser408). |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | Aminoacylase 1 (ACY1), a metalloenzyme that removes amide-linked ACY1 groups from amino acids and may play a role in regulating responses to oxidative stress. Both the C-terminal fragment found in the two-hybrid screen and full-length ACY1 co-immunoprecipitate with SphK1. Though both C-terminal and full-length proteins slightly reduce SphK1 activity measured in vitro, the C-terminal fragment inhibits while full-length ACY1 potentiates the effects of SphK1 on proliferation and apoptosis. It suggested that ACY1 physically interacts with SphK1 and may influence its physiological functions. As a homodimeric zinc-binding enzyme, Aminoacylase 1 catalyzes the hydrolysis of N alpha-acylated amino acids. Deficiency of Aminoacylase 1 due to mutations in the Aminoacylase 1 (ACY1) gene follows an autosomal-recessive trait of inheritance and is characterized by accumulation of N-acetyl amino acids in the urine. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Human ACY1 / Aminoacylase-1 protein (TMPY-01058) |
| 抗原种属 | Human |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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计算器
比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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