Powder: -20°C for 3 years
In solvent: -80°C for 2 years
Nalfurafine 是一种有效且特异性的 G 蛋白偏倚 κ-阿片受体激动剂，具有高转化潜力。 Nalfurafine 增强了 MOR 靶向镇痛药的生物学作用，可用于尿毒症瘙痒症的相关研究。
| 产品描述 | Nalfurafine is an effective and selective agonist of G protein-biased κ-opioid receptor with high translational potential. Nalfurafine enhances the therapeutic potential of MOR-targeting analgesics and can be used for uremic pruritis treatment studies. |
| 体内活性 | Nalfurafine (4 μg/kg; s.c.) increased the inhibition of the acetic acid-induced abdominal constriction in a dose-dependent manner, inhibited the abdominal constriction reaching its peak 30 min after injection, gradually declined, and returned to the preinjection level 4 hr after[1]. Nalfurafine (0.015 mg/kg; s.c.) combines with EOM-salvinorin-B produced spinal antinociception equivalent to 5 mg/kg. Nalfurafine also enhanced the supraspinal analgesic effect of 5 mg/kg morphine[2]. |
| 别名 | TRK-820 |
| 分子量 | 476.573 |
| 分子式 | C28H32N2O5 |
| CAS No. | 152657-84-6 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
( < 1 mg/ml refers to the product slightly soluble or insoluble )
参考文献
剂量换算对于不同动物的给药剂量换算，您也可以参考 更多
体内实验配液计算器计算器bottom
您可能有的问题的答案可以在抑制剂处理说明中找到，包括如何准备库存溶液，如何存储产品，以及基于细胞的分析和动物实验需要特别注意的问题。
Nalfurafine 152657-84-6 Endocrinology/Hormones GPCR/G Protein Neuroscience Opioid Receptor 纳呋拉啡 pruritis uremic inhibit TRK 820 Inhibitor agonist analgesic TRK820 TRK-820 inhibitor
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