5-HT Receptor

5-hydroxytryptamine receptors or 5-HT receptors, or serotonin receptors, are a group of G protein-coupled receptor and ligand-gated ion channels found in the central and peripheral nervous systems. They mediate both excitatory and inhibitory neurotransmission.

Cat. No.	Product Name	CAS No.	Purity
T79684	5-HT6R antagonist 1 化合物 5-HT6R antagonist 1		98%
T79684	5-HT6R antagonist 1（Compound 8）是一款具有突出代谢稳定性的5-HT6R拮抗剂（Ki: 5 nM），能有效抑制血小板聚集，并可逆转由MK-801引起的大鼠记忆障碍。此化合物在阿尔茨海默病（AD）的研究中有潜在应用价值。
T79802	5-HT2C agonist-3 化合物 5-HT2C agonist-3	2104810-18-4	98%
T79802	5-HT2C agonist-3 ((+)-19)为高选择性5-HT2C激动剂，其EC50为24 nM，Ki值为78 nM。该化合物表现出抗精神病药物样的活性，并能有效抑制安非他明诱导的多动症。
T79803	5-HT2C agonist-3 free base 化合物 5-HT2C agonist-3 free base	2104810-17-3	98%
T79803	5-HT2C agonist-3 ((+)-19) free base 是选择性的5-HT2C激动剂，具EC50: 24 nM及Ki: 78 nM值。该化合物展现出抗精神病药物样活性，并能阻断安非他明引起的多动症。
T79804	5-HT2 agonist-1 化合物 5-HT2 agonist-1	2708279-78-9	98%
T79804	5-HT2 agonist-1 (Compound 24) 是一种选择性5-HT2A, 5-HT2B和5-HT2C激动剂，其IC50值分别为10 nM, 8.3 nM和1.6 nM。5-HT2 agonist-1 free base主要用于研究治疗抑郁症、酗酒、吸烟与可卡因依赖、炎症、丛集性头痛、创伤后应激障碍(PTSD...
T79805	5-HT2 agonist-1 free base 化合物 5-HT2 agonist-1 free base	2708279-77-8	98%
T79805	5-HT2 agonist-1 (Compound 24) free base 是一种作用于5-HT2A, 5-HT2B和5-HT2C受体的激动剂，其IC50值分别为10 nM, 8.3 nM和1.6 nM。该化合物主要应用于研究抑郁症、酒精依赖、烟草及可卡因成瘾、炎症、丛集性头痛、创伤后应激障碍(PTSD)、癫痫以及其...
T79806	5-HT2A&5-HT2C agonist-1 化合物 5-HT2A&5-HT2C agonist-1	1640-02-4	98%
T79806	5-HT2A&5-HT2C agonist-1 (Example 2) 是一种选择性的5-HT2A和5-HT2C受体激动剂，其IC50值分别为196 nM和0.9 nM。本化合物主要应用于研究抑郁症、酒精依赖、烟草和可卡因成瘾、炎症、丛集性头痛、PTSD、癫痫等中枢神经系统相关疾病。
T79838	(S)-Bexicaserin 化合物 (S)-Bexicaserin	2035818-21-2	98%
T79838	(S)-Bexicaserin (化合物 2)，作为一种5-HT2C受体激动剂，展现了在肥胖和精神相关疾病研究中的应用潜力。
T15026	Cyamemazine 化合物 T15026	3546-03-0	98%
T15026	Cyamemazine, contains the phenothiazine chromophore, is a neuroleptic agent used as an anxiolytic. Cyamemazine is a potent 5-HT3 (Ki: 12 nM), 5-HT2A (Ki: 1.5 nM)...
T81335	PZ-1922 化合物 PZ-1922		98%
T81335	PZ-1922（Compound 16），是能穿透大脑屏障的5-HT6R/5-HT3R拮抗剂，其Ki值分别为17 nM和0.45 nM。该化合物还能可逆地抑制MAO-B（pIC50：8.93）。在大鼠的新物体识别(NOR)测试中，PZ-1922逆转了Scopolamine (SCOP)诱导的记忆缺陷；同样，在T迷宫测试中...
T12262L	NPS ALX Compound 4a dihydrochloride 化合物 T12262L	1781934-44-8	98%
T12262L	NPS ALX Compound 4a dihydrochloride is a potent and selective antagonist of 5-HT6 receptor (IC50 of 7.2 nM)
T10114	3-Hydroxy agomelatine 化合物 T10114	166526-99-4	98%
T10114	3-Hydroxy agomelatine is an Agomelatine metabolite and a 5-HT2C receptor antagonist (IC50: 3.2 μM; Ki: 1.8 μM).
TN3393	Alpha-Yohimbine 化合物 TN3393	131-03-3	98%
TN3393	Alpha-Yohimbine is a 5-HT1A receptor agonist, it is strong selective 2-adrenoceptor antagonist. Alpha-Yohimbine possess aphrodisiac effect.
T12716	RG-12915 化合物 T12716	136174-04-4	98%
T12716	RG-12915 is a selective antagonist of 5-HT3(IC50 value of 0.16 nM).
T12859	SB 243213 hydrochloride 化合物 T12859	200940-23-4	98%
T12859	SB 243213 hydrochloride is an orally active, selective and high-affinity antagonist of 5-hydroxytryptamine (5-HT)2C receptor(pKi of 9.37 and a pKb of 9.8).It has...
T11216	Eplivanserin (mixture) 化合物 T11216	130581-13-4	98%
T11216	Eplivanserin mixture is a selective serotonin reuptake inhibitor and a 5-HT2A receptor antagonist,
T16683	Pumosetrag Hydrochloride 化合物 T16683	194093-42-0	98%
T16683	Pumosetrag Hydrochloride is an orally available 5-HT3 partial agonist. It is developed for the treatment of irritable bowel syndrome and gastroesophageal reflux ...
T12046	Mirtazapine D3 米氮平 D3	1216678-68-0	98%
T12046	Mirtazapine D3 is a deuterium labeled Mirtazapine. Mirtazapine is an inhibitor of 5-HT receptor .
T10612	Brexpiprazole S-oxide 化合物 T10612	1191900-51-2	98%
T10612	Brexpiprazole S-oxide (DM-3411) is a main metabolite of Brexpiprazole. Brexpiprazole is a partial agonist of human 5-HT1A and dopamine receptors (Kis: 0.12 nM an...
T6959	PRX-08066 Maleic acid 化合物PRX-08066 Maleic acid	866206-55-5	98%
T6959	PRX-08066 Maleic acid 是一种选择性 5-HT2B 受体拮抗剂，IC50 为 3.4 nM，可防止 MCT 大鼠模型中肺动脉高压的严重程度。
T12806	(S)-Mirtazapine D3 化合物 T12806	T12806	98%
T12806	(S)-Mirtazapine D3 is a deuterium labeled (S)-Mirtazapine. (S)-Mirtazapine is a stereoselective antagonist of 5-HT2 receptor. (S)-Mirtazapine is metabolized by C...