visceral

N-(2-Hydroxypropyl)methacrylamide 用于合成共聚物，用于靶向递送内脏利什曼病中的抗寄生虫剂。

Alosetron hydrochloride (GR 68755) 是一种高选择性的 5-HT3 受体拮抗剂，可减轻清醒或麻醉犬直肠扩张的内脏伤害性效应，具有抗炎活性，用于肠易激综合征的研究。它阻断 5HT3 介导的豚鼠肌间和粘膜下神经元的快速去极化，IC50约为 55 nM。

GSK3179106 是选择性的、具有口服活性的RET 激酶抑制剂，对人和大鼠 RET 的 IC50 分别为 0.4 nM 和 0.2 nM。它能够减轻炎症后和应激引起的内脏超敏反应，对肠易激综合征具有潜在的应用价值。

INT-767 是一种高效的法尼类固醇 X 受体 (FXR) TGR5 双激动剂，可预防 NASH 并促进内脏脂肪棕色脂肪生成和线粒体功能，可用于研究非酒精性脂肪性肝炎。

DNDI-6148 具有抗实验性皮肤利什曼病活性，通过抑制利什曼原虫裂解和多聚腺苷酸化特异性因子 （CPSF3） 核酸内切酶起作用，可用于研究内脏利什曼病。

Stearic acid (Cetylacetic acid) 是长链饱和脂肪酸，存在于许多动植物油脂中。

Miltefosine (HePC) 是一种广谱抗微生物剂，是治疗内脏和皮肤利什曼病的药物。它是 CTP 磷酸胆碱胞苷基转移酶的抑制剂。

Phe-Met-Arg-Phe Like Peptide acetate (Pqdpflrfamide acetate)(98495-35-3 free base) 是一种来自蜗牛 Helix aspersa 的内脏和躯体肌肉的 FMRF 样肽。 FMRF (Phe-Met-Arg-Phe) 是一种由 4 个氨基酸残基组成的神经肽肽。

Solabegron (GW-427,353), is a selective agonist of β3 adrenergic receptors. In addition, Solabegron has been shown to produce visceral analgesia by releasing somatostatin from fat cells.

Acivicin (AT-125) 是一种由猪链霉菌产生的氯化氨基酸抗生素，是一种可以透过血脑屏障的 γ-谷氨酰转肽酶 (GGT) 抑制剂，具有抗癌和抗寄生虫活性，可用于研究内脏利什曼病。

PD 173212是一种阻断 N-型电压敏感性钙通道 (N-type voltage sensitive calcium channel, Cav2.2)的阻滞剂。PD173212的腹腔注射给药(0.0017-1.7 μmol kg)显著降低了2,4-二硝基苯磺酸(DNBS)诱导结肠炎小鼠的内脏超敏反应。

PD-217014为α2δ配体，展现出明显的内脏镇痛效果，并能剂量依赖地抑制内脏超敏。它有效地治疗痛觉过敏症状。

Dicentrine, (-)- (NSC-251699) 是一种在几种植物物种中发现的非卟啉生物碱，在小鼠内脏痛的急性模型中显示出显著的镇痛活性。

Oxyphenonium Free Base是一种季铵抗胆碱能药物，其外周副作用与ATROPINE相似。它主要用于辅助治疗胃和十二指肠溃疡，并缓解内脏痉挛。该化合物还可作为滴眼液使用，以引起散瞳效果。

PD-217014 is a GABA analog. It inhibits (3)H-gabapentin binding to alpha(2)delta subunit of voltage-gated calcium channels in a concentration-dependent manner (K(i) = 18 nmol/l). PD-217014 possesses visceral analgesic activity.

Neostibosan is an arsenic-containing parasitic agent. Due to the activity of arsenic on visceral L Ashmaniasis, one of the pentvalent antimony, which is less toxic, is synthesized and has potential activity on tumor cells.

Oxyphenonium bromide (Oxyfenon) 具有抗胆碱能活性，可用于治疗胃和十二指肠溃疡以及缓解内脏痉挛的研究。

(Ala13)-Apelin-13 acetate，一种 APJ 拮抗剂，可调节CRF 诱导的增强的结肠运动、内脏敏感性和肠屏障。

Urocortin II is a neuropeptide hormone and member of the corticotropin-releasing factor (CRF) family which includes mammalian CRF , urocortin , urocortin III , frog sauvagine, and piscine urotensin I.1 Mouse urocortin II shares 34 and 42% sequence homology with rat CRF and urocortin . It is expressed in mouse paraventricular, supraoptic, and arcuate nuclei of the hypothalamus, the locus coeruleus, and in motor nuclei of the brainstem and spinal ventral horn. Urocortin II selectively binds to CRF1 over CRF2 receptors (Kis = 0.66 and >100 nM, respectively) and induces cAMP production in CHO cells expressing CRF2 (EC50 = 0.14 nM). In vivo, urocortin II suppresses nighttime food intake by 35% in rats when administered intracerebroventricularly at a dose of 1 μg. Urocortin II (0.1 and 0.5 μg, i.c.v) stimulates fecal pellet output, increases distal colonic transit, and inhibits gastric emptying in mice.2References1. Reyes, T.M., Lewis, K., Perrin, M.H., et al. Urocortin II: A member of the corticotropin-releasing factor (CRF) neuropeptide family that is selectively bound by type 2 CRF receptors. Proc. Natl. Acad. Sci. U.S.A. 98(5), 2843-2848 (2001).2. Martinez, V., Wang, L., Million, M., et al. Urocortins and the regulation of gastrointestinal motor function and visceral pain. Peptides 25(10), 1733-1744 (2004). Urocortin II is a neuropeptide hormone and member of the corticotropin-releasing factor (CRF) family which includes mammalian CRF , urocortin , urocortin III , frog sauvagine, and piscine urotensin I.1 Mouse urocortin II shares 34 and 42% sequence homology with rat CRF and urocortin . It is expressed in mouse paraventricular, supraoptic, and arcuate nuclei of the hypothalamus, the locus coeruleus, and in motor nuclei of the brainstem and spinal ventral horn. Urocortin II selectively binds to CRF1 over CRF2 receptors (Kis = 0.66 and >100 nM, respectively) and induces cAMP production in CHO cells expressing CRF2 (EC50 = 0.14 nM). In vivo, urocortin II suppresses nighttime food intake by 35% in rats when administered intracerebroventricularly at a dose of 1 μg. Urocortin II (0.1 and 0.5 μg, i.c.v) stimulates fecal pellet output, increases distal colonic transit, and inhibits gastric emptying in mice.2 References1. Reyes, T.M., Lewis, K., Perrin, M.H., et al. Urocortin II: A member of the corticotropin-releasing factor (CRF) neuropeptide family that is selectively bound by type 2 CRF receptors. Proc. Natl. Acad. Sci. U.S.A. 98(5), 2843-2848 (2001).2. Martinez, V., Wang, L., Million, M., et al. Urocortins and the regulation of gastrointestinal motor function and visceral pain. Peptides 25(10), 1733-1744 (2004).

(2R S)-6-PNG (6-Prenylnaringenin) 是新型天然组蛋白脱乙酰酶抑制剂，具有抗癌抗肿瘤活性，可阻断T型钙通道可减轻小鼠的神经性和内脏疼痛。

LXE408 is an orally active, kinetoplastid-selective proteasome inhibitor, exhibiting non-competitive inhibitory effects. It demonstrates an IC50 of 0.04 μM for L. donovani proteasome and an EC50 of 0.04 μM for L. donovani. Moreover, LXE408 shows limited ability to traverse the blood-brain barrier. Hence, LXE408 holds promise for advancing research in the field of visceral leishmaniasis (VL).

LXE408 fumarate 是一种口服有效的，非竞争性的，动素体选择性蛋白酶体 (proteasome) 抑制剂。LXE408 fumarate 抑制 L. donovani 蛋白酶体 (IC50=0.04 μM) 和 L. donovani (EC50=0.04 μM)。LXE408 fumarate 具有较弱的透过血脑屏障能力。LXE408 fumarate 具有用于内脏利什曼病 (VL) 研究的潜力。

Helianorphin-19 is a high affinity, potent and selective κ-opioid receptor (KOR) agonist (Ki = 25 nM; EC50= 45 nM). Helianorphin-19 exhibits approximately 200-fold selectivity for KOR over μ and δ-opioid receptors.In vivoHelianorphin-19 shows potent peripheral analgesic efficacy in a mouse model of visceral pain without affecting motor coordination sedation.

Cav 3.2 inhibitor 1为T型钙离子通道(calcium channel)抑制剂，其与多巴胺受体(D2 receptor)的结合亲和力较低，主要应用于研究身体和内脏疼痛。