sulfation

Worenine (Worenin) 是一种从黄连中提取的物质。它在大鼠体内第一阶段代谢中显示出脱氢，氢化，羟基化和脱亚甲基反应。在大鼠体内 II 期代谢中显示为硫酸化和葡萄糖醛酸化反应。

1-Piperonylpiperazine (MDBP) 通过去亚甲基化过程代谢，然后甲基化为 N-(4-羟基-3-甲氧基苄基)哌嗪，随后部分发生葡糖醛酸化或硫酸化。1-Piperonylpiperazine 能改变 3,4-亚甲二氧基甲基苯丙胺 (MDMA) 在大脑和外周器官中的分布和代谢，同时具有抑制 MDMA 所引发神经毒性的作用。

Surfen dihydrochloride (Aminoquinuride dihydrochloride) 是一种有效的硫酸肝素小分子拮抗剂，具有抗菌和抗病毒活性，抑制炭疽致死因子、凝血因子 X 和致死因子。Surfen dihydrochloride 可抑制普通肝素和低分子量肝素的抗凝活性，抑制肝素的硫酸化和肝素裂解酶的降解。Surfen dihydrochloridn 抑制阻断硫酸乙酰肝素介导的 FGF2 结合和信号转导。Surfen 抑制 SEVI 和精液介导的 HIV 1 型感染增强。

Adenosine 5'-phosphosulfate (sodium salt)(APS)是硫代谢过程中的关键中间体和Adenosine 5'-phosphosulfate酶(APSK)的底物，被APSK代谢为高能硫酰供体PAPS(3'-phosphoadenosine-5'-phosphosulfate)。

Phenylephrine-3-O-sulfate is metabolite of the α1A-adrenergic receptor agonist phenylephrine formed via sulfation.

Hirudin (54-65; non-sulfated) is a desulfated peptide fragment of hirudin, an anticoagulant produced byH. medicinalis.1It inhibits fibrin clot formation induced by isolated bovine thrombin with an IC50value of 3.7 μM.2 1.Niehrs, C., Huttner, W.B., Carvallo, D., et al.Conversion of recombinant hirudin to the natural form by in vitro tyrosine sulfation. Differential substrate specificities of leech and bovine tyrosylprotein sulfotransferasesJ. Biol. Chem.265(16)9314-9318(1990) 2.Payne, M.H., Krstenansky, J.L., Yates, M.T., et al.Positional effects of sulfation in hirudin and hirudin PA related anticoagulant peptidesJ. Med. Chem.34(3)1184-1187(1991)

Sitagliptin N-sulfate is a phase II metabolite of the dipeptidyl peptidase 4 (DPP-4) inhibitor (-)-sitagliptin . Sitagliptin N-sulfate is formed via sulfation and has been found in rat bile following oral administration of (-)-sitagliptin.

Sulfatides are endogenous sulfoglycolipids with various biological activities in the central and peripheral nervous systems, pancreas, and immune system. They are produced from the combination of ceramide and UDP-galactose in the endoplasmic reticulum followed by sulfation in the Golgi apparatus. The ceramide portion contains variable fatty acid chain lengths, which are tissue- and pathology-dependent. Sulfatides are primarily found in the myelin sheath of oligodendrocytes and Schwann cells, with smaller chain lengths predominant during development and longer chain lengths predominant in mature cells. They accumulate in the lysosome of patients with metachromatic leukodystrophy, a disorder characterized by arylsulfatase A deficiency. Sulfatides are also located in pancreatic β-cells and inhibit insulin release from isolated rat pancreatic islet cells, suggesting a potential role in diabetes. Sulfatides can induce inflammation in glia in vitro and certain sulfatides, such as C24:1 3'-sulfo-galactosylceramide, can induce an immune response in vitro in mouse splenocytes. Sulfatides (bovine) (sodium salt) is a mixture of isolated bovine sulfatides.

Chst15-IN-1 是一种选择性、可逆且共价的 Chst15 酶抑制剂，能够抑制硫酸软骨素E（CS-E）及相关硫转移酶的硫酸化过程，从而减弱硫酸软骨素蛋白聚糖（CSPGs）的抑制效应，被认为具有促进神经修复的潜力。

Indoxyl Sulfate-D5 potassium salt is intended for use as an internal standard for the quantification of indoxyl sulfate by GC- or LC-MS. Indoxyl sulfate is a uremic toxin and a metabolite of tryptophan. It is formed via sulfation of indole,an intermediate generated from tryptophan by intestinal bacteria,by the sulfotransferase (SULT) isoform 1A1 variant 2 (SULT1A1*2)in the liver. Indoxyl sulfate activates the aryl hydrocarbon receptor (AhR)in HepG2 40/6 hepatoma cells (EC50 = 12.1 nM in a reporter assay). It also inhibits the organic anion transporter (OAT) isoforms OAT1 and OAT3 (Kis = 34.2 and 74.4 µM,respectively for the rat transporters)in S2 proximal tubule cells. Indoxyl sulfate (0.2 and 1 mM)increases superoxide anion and nitric oxide levels in isolated human mononuclear blood cells. It increases serum creatinine and blood urea nitrogen (BUN)levels in the 5/6 nephrectomized rat model of chronic renal failure when administered at a dose of 50 mg/kg.

p-Cresol (Standard)是 p-Cresol 的标准品，适用于定量分析、质量控制及生化实验等相关研究。p-Cresol 是一种小分子酚类化合物，属于内源性代谢物，具有一定的亲脂性，在体内可与血浆蛋白高度结合。其代谢主要通过硫酸化和葡萄糖醛酸化等结合反应进行，未结合部分可经尿液排泄。

Tyrosylprotein Sulfotransferase 2 (TPST-2) 是 TPST 的一个亚型。Tyrosylprotein Sulfotransferase 是一种 54-50 kDa 的反式高尔基网络的完整膜糖蛋白，已在几乎所有被研究的组织中发现，催化通过该隔室的可溶性蛋白和膜蛋白的酪氨酸 O-硫酸化。

Adenosine 3'-phosphate 5'-phosphosulfate lithium 是聚糖磺化过程中的共底物。它用于高尔基体磷酸腺苷特异性 3'-磷酸酶-偶联磺基转移酶的测定，作为供体底物转移磺酸基团。

Adenosine 3'-phosphate 5'-phosphosulfate lithium 是聚糖磺化过程中的共底物。Adenosine 3'-phosphate 5'-phosphosulfate lithium 可以用作高尔基体磷酸腺苷特异性3'-磷酸酶偶联磺基转移酶测定中的供体底物，用于转移磺酸基。