rn-1

RN-1 dihydrochloride 是血脑屏障通透性的、不可逆的赖氨酸特异性脱甲基酶 1 (LSD1) 选择性抑制剂，IC50为 70 nM，对 LSD1 的选择性高于 MAO-A 和 MAO-B，IC50分别为 0.51 μM 和 2.785 μM。

RN-1747是瞬时受体电位阳离子通道 V 型亚家族成员4（TRPV4 ）的选择性激动剂，对 hTRPV4、mTRPV4 和 rTRPV4 的 EC50分别为0.77 μM、4.0 μM 和4.1 μM。RN-1747也是 TRPM8的拮抗剂，IC50值为4.0 μM。

RN-1665 是一种具有有效性和选择性的 TRPV4 受体拮抗剂。

RN-18是 HIV-1 病毒感染因子的一种拮抗剂。

BRN-103 was found to suppress the VEGF-induced phosphorylation of VEGF receptor 2 (VEGR2) and the activations of AKT and eNOS. Taken together, these results suggest that BRN-103 inhibits VEGF-mediated angiogenesis signaling in human endothelial cells.

RN-1734是TRPV4通道的选择性拮抗剂，拮抗 4αPDD 介导的 TRPV4 活化，作用于 hTRPV4, mTRPV4, 和 rTRPV4的IC50分别为 2.3 μM、5.9 μM、3.2 μM。RN-1734能显著降低白细胞介素 1β和肿瘤坏死因子 α 的产生，而不改变 olig2- 阳性细胞的数量。

Trastuzumab deruxtecan (T-DXd) 是一种具有抗癌抗肿瘤活性的抗体-活性分子偶联物 (ADC)，由靶向人表皮生长因子受体 2 （HER2） 的单克隆抗体与拓扑异构酶 I 抑制剂 （DXd） 偶联而成。Trastuzumab deruxtecan对 HER2 阳性乳腺癌和胃癌的治疗有改善作用。

ARN19702 是一种选择性，具有口服活性的，可逆的，可透过血脑屏障的 N-乙酰乙醇胺酸酰胺酶 (NAAA) 抑制剂，对人 NAAA 的 IC50为 230 nM。ARN19702 具有广泛的镇痛作用。

Rilzabrutinib (PRN1008) 是一种可逆的、选择性的、有口服活性的布鲁顿氏酪氨酸激酶(BTK)共价抑制剂，其 IC50=1.3 nM。

ARN19874 is a selective, reversible uncompetitive N-acylphosphatidylethanolamine phospholipase D (NAPE-PLD) activity inhibitor. With an IC50 of ~34 μM[1].

Gentiakochianin（Swertianine,当药宁）是一种来自龙胆科植物(Gentianaceae)的蒽酮，具有血管舒张活性，能够诱导胶质瘤细胞周期阻滞在G(2) M期并抑制增殖，显著降低oxLDL诱导的EA.hy926细胞损伤, 抑制ROS水平，上调oxLDL抑制的Akt CREB eNOS信号通路活性。

Butyl benzoate是一种酯类化合物，广泛应用于生物化学实验和药物合成研究。

Tributyl phosphite is an alkyl phosphite. It is reported to inhibit carboxylesterase activity.

ARN14974 是一种有效的全身活性的胞内酸性神经酰胺酶抑制剂 (IC50=79 nM)，是一种苯并恶唑酮甲酰胺化合物。

Dibekacin is an antibiotic.

Diisopropyl tartrate is a reagent for kinetic resolution of racemic allylic alcohols and α-furfuryl amides. It acts by enantioselective epoxidation.

Cheirolin, an antioxidant and sulfonyl analog of sulforaphane, induces phase II enzyme activity and expression.

ARN14686 is an activity-based affinity probe for the detection of N-acylethanolamine acid amidase (NAAA) using click chemistry.

Carvone is an agonist of TRPV3 found in spearmint oil. It suppresses cell proliferation in prostate cancer cells and inhibits the growth of Dermatophagoides.

ARN14988 is a potent inhibitor of acid ceramidase (IC50 = 12.8 nM for the human enzyme). It inhibits acid ceramidase activity and increases levels of C16 dihydro ceramide and C16 ceramide in A375, G361, M14, MeWo, MNT-1, and SK-MEL-28 melanoma cells. ARN14988 also reduces growth of A375 and G361 melanoma cells (EC50s = 41.8 and 67.7 μM, respectively).

ARN19689 is an effective inhibitor of human NAAA, demonstrating high potency in the low nanomolar range (IC 50 = 0.042 μM). The compound acts through a non-covalent mechanism, highlighting its ability to interact with the enzyme for inhibition.

ARN1468 (compound 5) is a highly effective orally active inhibitor of serpins. Inhibition of serpins activity by ARN1468 enables release of proteases, thereby reducing prion accumulation. ARN1468 demonstrates pronounced anti-prion effects in ScGT1 RML, ScGT1 22L, ScN2a RML, and ScN2a 22L cell lines, with EC 50 values of 8.64, 19.3, 11.2, and 6.27 μM [1].

(R)-N-(1-(Naphthalen-1-yl)ethyl)-3-(3-(trifluoromethyl)phenyl)propanamide 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T66209，CAS号为 1005450-55-4。

(R)-N-[1-(5,6,7,8-Tetrahydronaphthalen-1-yl)ethyl]-3-[3-(trifluoromethyl)phenyl]-1-propylamine 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T66787，CAS号为 1229224-93-4。