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17

抑制剂 & 化合物

9

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T0609	Azobenzene 偶氮苯,Diazene,Diphenyldiazene	Others	Others
	Azobenzene (Diazene) 是一种光触发器，可用于设计和合成各种光响应系统。
T0352	Dibenzothiophene 二苯并噻吩,Imino semicarbazide,Diphenylene sulfide	Others	Others
	Dibenzothiophene (Imino semicarbazide) 是有机合成过程的中间体，是由两个苯环稠合到一个中心的噻吩环。
T20360	Chlorodiphenylmethane AI311230,AI3-11230,AI3 11230
	Chlorodiphenylmethane is an organic compound. It has two phenyl rings.
T31184	Dactylocycline E
	Dactylocyclines are novel tetracycline derivatives produced by Dactylosporangium SP. The fermentation of Dactylosporangium sp. (ATCC 53693) produced a mixture of tetracycline derivatives, from which several related tetracycline glycosides, known as rings,
T20583	1-Acetylferrocene Acetylferrocene,1Acetylferrocene,Acetoferrocene
	1-Acetylferrocene, an organoiron compound with the formula Fe, consists of ferrocene substituted by an acetyl group on one of the cyclopentadienyl rings. It is an orange, air-stable solid and is soluble in organic solvents.
T40157	Hyp-Phe-Phe
	Hyp-Phe-Phe is a tripeptide known for its strong aromatic interactions between the Phe rings, resulting in the formation of helical-like sheets and a cross helical architecture. Notably, Hyp-Phe-Phe exhibits excellent shear piezoelectricity properties, making it a valuable candidate for piezoelectric materials.
T28321	PD 122860 PD-122860,PD122860
	PD 122860 is a dihydropyridine with calcium channel blocking and sodium channel stimulating properties. In the rat heart, PD 122860 increased left ventricular contractility, decreased coronary resistance and altered the shape of the electrocardiogram T-wa
T69133	Etozolin HCl
	Etozolin HCl is a safe and effective diuretic agent in the treatment of acute cardiac failure. In isolated rings of guinea-pig aorta not responding to acetylcholine, the diuretic dexetozoline did not influence basal vascular tone but inhibited noradrenaline- and histamine-induced contractions. Dexetozoline has a very high bioavailability after oral administration and is fairly lipohilic. The half-life of etozolin is 2.5 h. Dexetozoline accumulates in cirrhosis.
T35270	YO-Pro 1 YO-Pro1,YO-Pro-1
	YO-Pro 1 是一种由苯并恶唑和喹啉环通过连接体连接而成的菁染料，在水中几乎没有荧光，但其荧光在插入双链DNA后大大增强，成为DNA浓度测定的基础，Ex/Em (结合DNA) = 491/509 nm。YO-Pro 1 可用于鉴定凋亡细胞。
T71870	CP21
	CP21 is an iron chelator that binds to iron in a 3:1 (ligand:iron) ratio. It is active against P. falciparum when used at concentrations of 10 and 100 µM. CP21 inhibits production of prostaglandin I2 induced by epinephrine, arachidonic acid, or A23187 in isolated rat aortic rings with IC50 values of 1.3, 1.3, and 1.4 mM, respectively. It inhibits glutamate-induced oxytosis, as well as decreases iodoacetic acid-induced cytotoxicity in an in vitro model of ischemia, in HT22 mouse hippocampal cells...
T36956	Bis-ANS dipotassium 4,4'-Dianilino-1,1'-binaphthyl-5,5'-disulfonic Acid,bis-ANS (potassium salt)
	bis-ANS is a high-affinity non-covalent extrinsic fluorescent dye used to analyze protein conformation.[1] Its predominant interaction with proteins is through its hydrophobic phenyl and naphthyl rings.[2] bis-ANS has an excitation maxima of 390 nm.[3] It has an emission maximum of 523 nm when free in solution but undergoes a blue shift with an increase in fluorescence intensity when bound to protein; for example, when bound to intestinal fatty acid binding protein (FAPB2) it has emission maxima...
T36465	Caylin-2
	Nutlin-3 is an activator of p53 that functions by inhibiting the interaction of p53 with MDM2, a negative regulator of p53 activity. Caylin-2 is a nutlin-3 analog in which trifluoromethyl groups have been substituted for chlorine on the 2 phenyl rings. At high concentrations, caylin-2 inhibits the growth of HCT116 cells with an IC50 of approximately 8 μM, making it about 10-fold less potent than nutlin-3. Interestingly, at concentrations between 5-100 nM, caylin-2 promotes the growth of HCT116 c...
T37620	Leukotriene C4 methyl ester
	Leukotriene C4 (LTC4) is the parent cysteinyl-leukotriene produced by the LTC4 synthase-catalyzed conjugation of glutathione to LTA4. LTC4 is produced by neutrophils, macrophages, and mast cells, and by transcellular metabolism in platelets. It is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A) and exhibits potent smooth muscle contracting activity. LTC4-induced bronchoconstriction and enhanced vascular permeability contribute to the pathogenesis of asthma and acute all...
T36464	Caylin-1
	Nutlin-3 is an activator of p53 that functions by inhibiting the interaction of p53 with MDM2, a negative regulator of p53 activity. Caylin-1 is a nutlin-3 analog which contains chlorine substituents at the 3 and 4 positions on two of the phenyl rings rather than a single 4-chloro as seen in nutlin-3. At high concentrations, caylin-1 inhibits the growth of HCT116 cells with an IC50 value of approximately 7 μM, making it about 7-fold less potent than nutlin-3 in the same assay. Interestingly, at ...
T37794	Rec 15/2615 (hydrochloride)
	Rec 15/2615 is an antagonist of α1B-adrenergic receptors (α1B-ARs; Ki = 0.45 nM for the recombinant human receptor).1 It selectively inhibits α1B-ARs over α1A-, α1D-, and α1L-ARs (Kis = 7.59, 10.23, and 49 nM, respectively). Rec 15/2615 inhibits norepinephrine-induced contractions of isolated rabbit prostate and urethral strips (Kis = 100 and 316.2 nM, respectively), as well as reduces norepinephrine-induced contractions of chloroethylclonidine-precontracted isolated rabbit aortic rings (Ki = 50...
T36777	Thrombin Receptor Agonist Peptide (trifluoroacetate salt)
	Thrombin receptor agonist peptide (TRAP-14) is a 14-amino acid peptide agonist of the α-thrombin receptor. It induces aggregation of washed platelets as well as platelets in citrated and hirudin plasma. TRAP-14 (100 μM) increases the cytosolic calcium concentration in isolated guinea pig pulmonary smooth muscle cells 5-fold over baseline. It increases pulmonary arterial pressure in isolated guinea pig lung when used at a concentration of 1 μM, which is comparable to the effect induced by 10 nM α...
T83662	2,3-dinor-8-iso Prostaglandin F1α 2,3-dinor-8-iso PGF1α,2,3-dinor-iPF1α-III,2,3-dinor-5,6-dihydro-15-F2t-Isoprostane,2,3-dinor-5,6-dihydro-15-F2t-IsoP
	2,3-dinor-8-iso Prostaglandin F1α（2,3-dinor-8-iso PGF1α）是一种异前列腺素和花生四烯酸的活性代谢物，也是血小板聚集抑制剂8-iso PGF2α的产物。它通过花生四烯酸的非酶促自由基过氧化作用形成。2,3-dinor-8-iso PGF1α在孤立的猪视网膜和大脑微血管中引起血管收缩（EC50s分别为12.8和18.5 nM），但在31 µM的浓度下使用时不会引起孤立的大鼠主动脉环的收缩。在1 µM的浓度下使用时，它能增加孤立的猪大脑切片中的血栓素B2（TXB2）水平，这一效应可以通过血栓素A合成酶抑制剂CGS 12970、电压门控钙通道抑制剂SKF 96365或烟碱型乙酰胆碱受体（nAChR）拮抗剂α-conotoxin来逆转。

化合物

Cat.No: T0609

Synonym: 偶氮苯,Diazene,Diphenyldiazene

Target: Others

Dibenzothiophene

Cat.No: T0352

Synonym: 二苯并噻吩,Imino semicarbazide,Diphenylene sulfide

Target: Others

Chlorodiphenylmethane

Cat.No: T20360

Synonym: AI311230,AI3-11230,AI3 11230

Dactylocycline E

Cat.No: T31184

1-Acetylferrocene

Cat.No: T20583

Synonym: Acetylferrocene,1Acetylferrocene,Acetoferrocene

Cat.No: T40157

Cat.No: T28321

Synonym: PD-122860,PD122860

Cat.No: T69133

Cat.No: T35270

Synonym: YO-Pro1,YO-Pro-1

Cat.No: T71870

Bis-ANS dipotassium

Cat.No: T36956

Synonym: 4,4'-Dianilino-1,1'-binaphthyl-5,5'-disulfonic Acid,bis-ANS (potassium salt)

Cat.No: T36465

Leukotriene C4 methyl ester

Cat.No: T37620

Cat.No: T36464

Rec 15/2615 (hydrochloride)

Cat.No: T37794

Thrombin Receptor Agonist Peptide (trifluoroacetate salt)

Cat.No: T36777

2,3-dinor-8-iso Prostaglandin F1α

Cat.No: T83662

Synonym: 2,3-dinor-8-iso PGF1α,2,3-dinor-iPF1α-III,2,3-dinor-5,6-dihydro-15-F2t-Isoprostane,2,3-dinor-5,6-dihydro-15-F2t-IsoP

Cat. No.	Product Name	Target	Signaling Pathways
T7437	3-(3-Hydroxyphenyl)propionic Acid m-Hydroxyphenylpropionic acid,3-Hydroxyhydrocinnamic acid,3-(3-羟基苯基)丙酸	Others; Endogenous Metabolite	Metabolism; Others
	3-(3-Hydroxyphenyl)propionic Acid (m-Hydroxyphenylpropionic acid) 是一种黄酮类代谢产物，由人体微生物区系形成，具有舒张血管的特性。
T2864	Lycopene 番茄红素,ψ,ψ-Carotene	Reactive Oxygen Species; ROS	Immunology/Inflammation; Metabolism; NF-κB
	Lycopene (ψ,ψ-Carotene) 是一种番茄及其产品和其他红色水果和蔬菜中天然存在的类胡萝卜素，具有抗氧化活性。
T38141	Glycerophospholipids, cephalins Phosphatidylethanolamines (egg)
	Glycerophospholipids, cephalins (Phosphatidylethanolamines (egg)) 是一种从鸡蛋中分离出来的磷脂酰乙醇胺的混合物，在 sn-1和 sn-2位置有各种脂肪酰基。Glycerophospholipids, cephalins 完全水解可得到1mol 的甘油、磷酸、乙醇胺和2mol 的脂肪酸。Phosphatidylethanolamines 在膜融合和细胞分裂过程中收缩环的拆卸中起作用，可调节膜的弯曲度。Phosphatidylethanolamines 能够在没有任何蛋白质或核酸的帮助下传播传染性朊病毒。Phosphatidylethanolamines 在细菌膜中的主要作用之一是分散由阴离子膜磷脂引起的负电荷。
T20238	Dibenzofuran NSC-1245,NSC 1245,NSC1245
	Dibenzofuran is a heterocyclic organic compound. It has two benzene rings fused to a central furan ring.
TN4975	Scutebata C	Others	Others
	Scutebata B possesses a rare alpha-hydroxy group in its alpha,beta-unsaturated lactone rings.
TN1246	3-Deoxysappanone B	Others	Others
	3-Deoxysappanone B has vasorelaxation effects, it can mediate endothelium- independent vasodilator action in rat thoracic aortic rings.
TN3904	Dysolenticin J	Others	Others
	Dysolenticin J shows significant vasodilative effects on intact rat aortic rings with a diastolic degree of 87.4% at 10 ug/mL.
T83596	(+)-Osbeckic acid
	(+)-Osbeckic acid，一种Tartary Buckwheat中提取的血管松弛剂，对Sprague-Dawley大鼠胸主动脉环展现出显著的血管舒张效应，其半数有效浓度(EC50)为887 μM。
TN4819	(-)-Praeruptorin A	ATPase; IL Receptor; Calcium Channel; P-gp	Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Neuroscience
	(-)-Praeruptorin A has anti-inflammatory, anti-contractile and anti-hyperplasia activities, it exerts distinct relaxant effects on isolated rat aorta rings dependent on endothelium and nitric oxide synthesis;it also can significantly suppress airway inflammation and airway remodeling induced by ovalbumin challenge, and is a potential candidate for the treatment of asthma. (-)-Praeruptorin A resensitizes Pgp-mediated MDR (Pgp-MDR) cancer cells to cancer drugs.

天然产物

3-(3-Hydroxyphenyl)propionic Acid

Cat.No: T7437

Synonym: m-Hydroxyphenylpropionic acid,3-Hydroxyhydrocinnamic acid,3-(3-羟基苯基)丙酸

Target: Others, Endogenous Metabolite

Cat.No: T2864

Synonym: 番茄红素,ψ,ψ-Carotene

Target: Reactive Oxygen Species, ROS

Glycerophospholipids, cephalins

Cat.No: T38141

Synonym: Phosphatidylethanolamines (egg)

Cat.No: T20238

Synonym: NSC-1245,NSC 1245,NSC1245

Cat.No: TN4975

Target: Others

3-Deoxysappanone B

Cat.No: TN1246

Target: Others

Cat.No: TN3904

Target: Others

(+)-Osbeckic acid

Cat.No: T83596

(-)-Praeruptorin A

Cat.No: TN4819

Target: ATPase, IL Receptor, Calcium Channel, P-gp

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