r-ptp-ζ

Expression system: HEK293 Cells
Length: 26-747, Partial
Activity: Not Tested

Expression system: E. coli
Length: 36-300, partial
Activity: Not Tested

Expression system: P. pastoris (Yeast)
Length: 36-300, Partial
Activity: Not Tested

PTPRS Protein, Human, Recombinant (His) is expressed in HEK293 Cells. The accession number is Q13332.

Expression system: E. coli
Length: 576-950, Partial
Activity: Not Tested

Expression system: E. coli
Length: 1631-1907, Partial
Activity: Not Tested

Expression system: Baculovirus Insect Cells
Length: 1631-1907, Partial
Activity: Not Tested

DEP1 PTPRJ (Receptor-type tyrosine-protein phosphatase eta) is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes, including cell growth, differentiation, mitotic cycle, and oncogenic transformation. DEP1 PTPRJ possesses an extracellular region containing five fibronectin type III repeats, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. DEP1 PTPRJ is present in all hematopoietic lineages, and was shown to negatively regulate T cell receptor signaling possibly through interfering with the phosphorylation of Phospholipase C Gamma 1 and Linker for Activation of T Cells. This protein can also dephosphorylate the PDGF beta receptor, and may be involved in UV-induced signal transduction. In stable MCF-7 cell lines, induction of DEP-1 expression inhibited breast cancer cell growth by 5-10-fold. These data describe PTPs expressed and regulated in breast cancer cell lines during differentiation and identify one PTP, DEP-1, that inhibits the growth of breast cancer cells in vitro.

Expression system: E. coli
Length: 1643-1997, Cytoplasmic Domain
Activity: Not Tested

Expression system: E. coli
Length: 687-979, Partial
Activity: Not Tested

Expression system: P. pastoris (Yeast)
Length: 1643-1997, Cytoplasmic Domain
Activity: Not Tested