PTPRA is reported to be involved in cancer development and progression through activating the Src family kinase (SFK) signaling pathways. The higher PTPRA level was associated with worse prognosis of SCC patients and PTPRA could promote the cell cycle progression through stimulating the c-Src signaling pathways. The PTPRA gene, which encodes the protein RPTP-alpha, is critical to neurodevelopment. Previous linkage studies, genome-wide association studies, controlled expression analyses and animal models support an association with both schizophrenia and autism spectrum disorders, both of which share a substantial portion of genetic risks.
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
50 μg | ¥ 3,820 | 5日内发货 | ||
500 μg | ¥ 24,900 | 5日内发货 |
生物活性 | 1. Measured by its ability to bind biotinylated recombinant mouse SRC in a functional ELISA. 2. Measured by its ability to cleave a substrate, pNitrophenyl phosphate (pNPP). The specific activity is >40000 pmol/min/μg. |
产品描述 | PTPRA is reported to be involved in cancer development and progression through activating the Src family kinase (SFK) signaling pathways. The higher PTPRA level was associated with worse prognosis of SCC patients and PTPRA could promote the cell cycle progression through stimulating the c-Src signaling pathways. The PTPRA gene, which encodes the protein RPTP-alpha, is critical to neurodevelopment. Previous linkage studies, genome-wide association studies, controlled expression analyses and animal models support an association with both schizophrenia and autism spectrum disorders, both of which share a substantial portion of genetic risks. |
种属 | Human |
表达系统 | Baculovirus Insect Cells |
标签 | His, GST |
蛋白编号 | P18433-2 |
别名 | LRP, PTP α/PTPRA Protein, Human, Recombinant (aa 174-793, His & GST), HPTPA, R-PTP-α, HEPTP, protein tyrosine phosphatase, receptor type, A, HPTPalpha, HPTPα, RPTPA, PTPRL2, HLPR, PTPA, R-PTP-alpha |
蛋白构建 | The Human PTPRA isoform 2 (P18433-2) cytoplasmic domain (Ala 174-Lys 793) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus. |
蛋白纯度 | > 90 % as determined by SDS-PAGE |
分子量 | 99 kDa (predicted) |
内毒素 | < 1.0 EU/μg of the protein as determined by the LAL method. |
缓冲液 | Supplied as sterile 20 mM Tris, 500 mM NaCl, pH 7.4, 20% gly, 3 mM DTT. |
复溶方法 | A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information. |
存储 |
It is recommended to store the product under sterile conditions at -20℃ to -80℃. Samples are stable for up to 12 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
运输方式 |
In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice. |
研究背景 | PTPRA is reported to be involved in cancer development and progression through activating the Src family kinase (SFK) signaling pathways. The higher PTPRA level was associated with worse prognosis of SCC patients and PTPRA could promote the cell cycle progression through stimulating the c-Src signaling pathways. The PTPRA gene, which encodes the protein RPTP-alpha, is critical to neurodevelopment. Previous linkage studies, genome-wide association studies, controlled expression analyses and animal models support an association with both schizophrenia and autism spectrum disorders, both of which share a substantial portion of genetic risks. |
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PTP alpha/PTPRA Protein, Human, Recombinant (aa 174-793, His & GST) LRP PTP α/PTPRA Protein, Human, Recombinant (aa 174-793, His & GST) HPTPA R-PTP-α HEPTP protein tyrosine phosphatase, receptor type, A HPTPalpha HPTPα RPTPA PTPRL 2 PTPRL2 HLPR PTPA PTPRL-2 R-PTP-alpha recombinant recombinant-proteins proteins protein