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PTP alpha/PTPRA Protein, Human, Recombinant (aa 174-793, His & GST)

Synonyms: R-PTP-α, R-PTP-alpha, RPTPA, PTPRL2, PTPA, PTP α/PTPRA Protein, Human, Recombinant (aa 174-793, His & GST), protein tyrosine phosphatase, receptor type, A, LRP, HPTPα, HPTPalpha, HPTPA, HLPR, HEPTP
货号 TMPY-02511 一键复制产品信息
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26年秋季促销
26年新产品线折扣促销活动

PTPRA is reported to be involved in cancer development and progression through activating the Src family kinase (SFK) signaling pathways. The higher PTPRA level was associated with worse prognosis of SCC patients and PTPRA could promote the cell cycle progression through stimulating the c-Src signaling pathways. The PTPRA gene, which encodes the protein RPTP-alpha, is critical to neurodevelopment. Previous linkage studies, genome-wide association studies, controlled expression analyses and animal models support an association with both schizophrenia and autism spectrum disorders, both of which share a substantial portion of genetic risks.

PTP alpha/PTPRA Protein, Human, Recombinant (aa 174-793, His & GST)

一键复制产品信息
Rating icon 还可以
26年秋季促销
26年新产品线折扣促销活动
货号 TMPY-02511

别名 R-PTP-α, R-PTP-alpha, RPTPA, PTPRL2, PTPA, PTP α/PTPRA Protein, Human, Recombinant (aa 174-793, His & GST), protein tyrosine phosphatase, receptor type, A, LRP, HPTPα, HPTPalpha, HPTPA, HLPR, HEPTP

PTPRA is reported to be involved in cancer development and progression through activating the Src family kinase (SFK) signaling pathways. The higher PTPRA level was associated with worse prognosis of SCC patients and PTPRA could promote the cell cycle progression through stimulating the c-Src signaling pathways. The PTPRA gene, which encodes the protein RPTP-alpha, is critical to neurodevelopment. Previous linkage studies, genome-wide association studies, controlled expression analyses and animal models support an association with both schizophrenia and autism spectrum disorders, both of which share a substantial portion of genetic risks.

PTP alpha/PTPRA Protein, Human, Recombinant (aa 174-793, His & GST)
规格价格库存数量
10 μg
¥ 1,130
6-8日内发货
20 μg
¥ 1,930
5日内发货
50 μg
¥ 3,820
5日内发货
100 μg
¥ 6,730
5日内发货
200 μg
¥ 11,800
5日内发货
500 μg
¥ 28,800
5日内发货
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产品介绍

生物活性
产品描述
PTPRA is reported to be involved in cancer development and progression through activating the Src family kinase (SFK) signaling pathways. The higher PTPRA level was associated with worse prognosis of SCC patients and PTPRA could promote the cell cycle progression through stimulating the c-Src signaling pathways. The PTPRA gene, which encodes the protein RPTP-alpha, is critical to neurodevelopment. Previous linkage studies, genome-wide association studies, controlled expression analyses and animal models support an association with both schizophrenia and autism spectrum disorders, both of which share a substantial portion of genetic risks.
生物活性
1. Measured by its ability to bind biotinylated recombinant mouse SRC in a functional ELISA.
2. Measured by its ability to cleave a substrate, pNitrophenyl phosphate (pNPP). The specific activity is >40000 pmol/min/μg.
研究背景
PTPRA is reported to be involved in cancer development and progression through activating the Src family kinase (SFK) signaling pathways. The higher PTPRA level was associated with worse prognosis of SCC patients and PTPRA could promote the cell cycle progression through stimulating the c-Src signaling pathways. The PTPRA gene, which encodes the protein RPTP-alpha, is critical to neurodevelopment. Previous linkage studies, genome-wide association studies, controlled expression analyses and animal models support an association with both schizophrenia and autism spectrum disorders, both of which share a substantial portion of genetic risks.
种属
Human
表达系统
Baculovirus Insect Cells
标签
His, GST
蛋白编号P18433-2
蛋白构建
A DNA sequence encoding the human PTPRA isoform 2 (P18433-2) cytoplasmic domain (Ala 174-Lys 793) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus. Predicted N terminal: Met
蛋白纯度
> 90 % as determined by SDS-PAGE
蛋白性状
Solution
缓冲液
Supplied as sterile 20 mM Tris, 500 mM NaCl, pH 7.4, 20% gly, 3 mM DTT.
复溶方法
A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
别名
R-PTP-α, R-PTP-alpha, RPTPA, PTPRL2, PTPA, PTP α/PTPRA Protein, Human, Recombinant (aa 174-793, His & GST), protein tyrosine phosphatase, receptor type, A, LRP, HPTPα, HPTPalpha, HPTPA, HLPR, HEPTP
内毒素< 1.0 EU/μg of the protein as determined by the LAL method.
化学信息
分子量99 kDa (predicted); 90 kDa (reducing conditions)
储存&溶解度
运输方式In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
存储

It is recommended to store the product under sterile conditions at -20°C to -80°C. Samples are stable for up to 12 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

实际储存温度请以COA为准

计算器

  • 复溶 计算器
  • 重组蛋白稀释 计算器
  • 比活力 计算器

剂量转换

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技术支持

请阅读 重组蛋白用户指南 了解更多具体信息.

关键词

PTPRL-2PTPRL 2
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