ppt

PPT is a modulator of water-heme interactions of CYP2C9d and CYP125A1 in low-spin P450 complexes.

Propyl pyrazole triol (PPT) 是雌激素受体 α(ERα)选择性激动剂。它对 ERα 的相对结合亲和力 (ERα: 49%) 比雌激素受体 β (ERβ: 0.12%) 高 410 倍。

(20S)-Protopanaxatriol (g-PPT) 是人参皂苷的代谢物，通过糖皮质激素受体和雌激素受体起作用，同时为LXRα的抑制剂，具有广泛的抗癌活性。

PPTN 是一种有效，高亲和力，竞争性和高选择性的 P2Y14 受体拮抗剂，KB 为 434 pM。PPTN 对 P2Y1，P2Y2，P2Y4，P2Y6，P2Y11，P2Y12 或 P2Y13 受体无激动剂或拮抗剂作用。具有抗炎和免疫活性。

PPTN hydrochloride 是有效的、高亲和力的、竞争性的、高度选择性的P2Y14受体拮抗剂 (KB: 434 pM)，但 P2Y1，P2Y2，P2Y4，P2Y6，P2Y11，P2Y12 或 P2Y13 受体无激动剂或拮抗剂活性，表现出抗炎和抗免疫作用。

PptT-IN-4 (Compound 3a) 为PptT抑制剂，IC50为0.71 μM。其对MtbH37Rv的MIC值为42 μM，并且还能抑制hERG、hCav1.2和hNav1.5通道，对应IC50s分别为11 μM、8.1 μM、6.9 μM。

ppTG20，一种两亲性细胞穿透肽 (KALA)，主要应用于基因转染。该肽与 DNA 结合后，能够破坏细胞膜的稳定性，从而促进 DNA 的成功转染。

PPTN Mesylate is an effective and highly selective antagonist of the P2Y14 receptor.

DMA-CPPTL is a prodrug of CPPTL which induces apoptosis in a dose-dependent manner via the ROS/JNK pathway in acute myeloid leukemia.

PptT-IN-2 (compound 5k) is a highly effective inhibitor of phosphopantetheinyl phosphoryl transferase (PptT), with an IC50 of 2.5 μM. PptT is an indispensable enzyme crucial for synthesizing cellular lipids and virulence factors in Mycobacterium tuberculosis. Therefore, PptT-IN-2 holds great promise for further investigations into tuberculosis research [1].

PptT-IN-3 (compound 5p) is a powerful inhibitor (IC 50 = 3.5 μM) of phosphopantetheinyl phosphoryl transferase (PptT), an indispensable enzyme involved in the synthesis of cellular lipids and virulence factors in Mycobacterium tuberculosis. This compound, PptT-IN-3, holds promise for tuberculosis research [1].

PptT-IN-1 (compound 5j) is a highly potent inhibitor (IC50: 2.8 μM) of phosphopantetheinyl phosphoryl transferase (PptT), a crucial enzyme involved in the biosynthesis of cellular lipids and virulence factors in Mycobacterium tuberculosis. This compound shows considerable potential for tuberculosis research [1].

C15AlkOPP Tetrabutylamine salt 是一种 可点击 的farnesyl diphosphate (FPP)的炔烃修饰类似物。

C15AlkOPP Tetrabutylamine salt (1：2)是一种FPP 类似物，具有炔基，允许前戊酰化后的蛋白质标记。C15AlkOPP Tetrabutylamine salt (1：2)可用于异戊二烯组学分析。

HMBPP triammonium is a stimulator of gamma delta T cells.

LPP Tripeptide 是一种降血压作用的三肽，常用于高血压的研究领域。

DMAPP triammonium (Dimethylallyl diphosphate triammonium) 是一种异戊二烯类化合物的前提物质之一，参与甲羟戊酸 (MVA) 途径，可用于研究与代谢相关的疾病。

Lqvtdsglyrcviyhpp TFA 是一种由17个氨基酸组成的多肽，是可穿透血脑屏障的触发受体1 (TREM-1) 抑制剂，具有潜在的抗癌活性，可用于研究皮肤癌和胰腺癌。

Mu-6S-Palm-β-Glc is a fluorogenic substrate of palmitoyl-protein thioesterase (PPT, also known as CLN1), a lysosomal hydrolase that removes long-chain fatty acyl groups from modified cysteine residues in proteins. Mu-6S-Palm-β-Glc is cleaved by PPT CLN1 to release the fluorescent moiety 4-methylumbelliferyl (4-MU). 4-MU fluorescence is pH-dependent with excitation maxima of 320 and 360 nm at low (1.97-6.72) and high (7.12-10.3) pH, respectively, and an emission maximum ranging from 445 to 455 nM, increasing as pH decreases. This substrate is used in assays that measure PPT activity, which is commonly deficient in the neurodegenerative disorder known as infantile neuronal ceroid lipofuscinosis.