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抑制剂&激动剂
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TargetMol产品目录中 "pip2"的结果
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TargetMol产品目录中 "

pip2

"的结果
  • 抑制剂&激动剂
    13
    TargetMol | Inhibitors_Agonists
  • 重组蛋白
    4
    TargetMol | Recombinant_Protein
  • 多肽产品
    4
    TargetMol | Peptide_Products
  • PROTAC
    1
    TargetMol | PROTAC
  • 分子与细胞研究
    1
    TargetMol | Inhibitors_Agonists
  • UNC3230
    UNC 3230
    T234981031602-63-7
    UNC3230 是一种 ATP 竞争性的磷脂酰肌醇 4 磷酸 5 激酶 1C 型 (PIP5K1C) 选择性抑制剂,其IC50约为 41 nM。它还可抑制PIP4K2C,但对其他调节磷酸肌醇水平的脂质激酶无抑制作用。它具有缓解疼痛和抗癌特性。
    • ¥ 458
    In stock
    规格
    数量
  • NA 382
    T70683143086-33-3
    NA 382 is a staurosporine derivative that inhibits multidrug resistance.
    • ¥ 28200
    10-14周
    规格
    数量
  • (3S)Lenalidomide-5-Pip-C-Pip-2C-Pip
    T200166
    (3S)Lenalidomide-5-Pip-C-Pip-2C-Pip 属于 E3 泛素酶配体+连接子偶联物 (E3 Ligase Ligand-Linker Conjugates) 的类别。该化合物主要用于合成 PROTACCbl-b-IN-1。
    • 待询
    规格
    数量
  • Inavolisib
    RG6114, GDC-0077
    T153752060571-02-8
    Inavolisib (GDC-0077) 是一种可口服的选择性PI3Kα抑制剂,IC50值为0.038 nM。它通过与 PI3K 的 ATP 结合位点结合而发挥其活性,从而抑制了 PIP2PIP3 的磷酸化。
    • ¥ 1580
    In stock
    规格
    数量
    TargetMol | Inhibitor Hot
  • PF-06843195
    PF06843195
    T363082067281-51-8
    PF-06843195 是一种高效和选择性的 PI3Kα 抑制剂,与PI3Kα的活性位点结合,阻止其催化PIP2转化PIP3,进而抑制AKT的激活,在体内外均具有抗肿瘤活性。
    • ¥ 1500
    In stock
    规格
    数量
  • PtdIns-(1,2-dioctanoyl) (sodium salt)
    T36937899827-36-2
    The phosphatidylinositol (PtdIns) phosphates represent a small percentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals. PtdIns-(1,2-dioctanoyl) is a synthetic analog of natural phosphatidylinositol (PtdIns) containing C8:0 fatty acids at the sn-1 and sn-2 positions. The compound features the same inositol and diacyl glycerol (DAG) stereochemistry as that of the natural compound. The short fatty acid chains of this analog, compared to naturally-occurring PtdIns, gives it different physical properties including high solubility in aqueous media. PtdIns are phosphorylated to mono- (PtdIns-P; PIP), di- (PtdIns-P2; PIP2), and triphosphates (PtdIns-P3; PIP3). Hydrolysis of PtdIns-(4,5)-P2 by phosphoinositide (PI)-specific phospholipase C generates inositol triphosphate (IP3) and DAG which are key second messengers in an intricate biochemical signal transduction cascade.
    • 待估
    35日内发货
    规格
    数量
  • PtdIns-(3)-P1 (1,2-dioctanoyl) (sodium salt)
    PtdIns-(3)-P1 (1,2-dioctanoyl) (sodium salt)
    T36938299216-98-1
    The phosphatidylinositol (PtdIns) phosphates represent a small percentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals. PtdIns-(3)-P1 (1,2-dioctanoyl) is a synthetic analog of natural PtdIns featuring C8:0 fatty acids at the sn-1 and sn-2 positions. The compound features the same inositol and DAG stereochemistry as the natural compound. PtdIns-(3)-P1 can be phosphorylated to di- (PtdIns-P2; PIP2) and triphosphates (PtdIns-P3; PIP3) by phosphatidyl inositol (PI)-specific kinases.
    • 待估
    35日内发货
    规格
    数量
  • PtdIns-(4)-P1 (1,2-dioctanoyl) (ammonium salt)
    PtdIns-(4)-P1 (1,2-dioctanoyl) (ammonium salt)
    T370301246303-11-6
    The phosphatidylinositol (PtdIns) phosphates represent a small percentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals. PtdIns-(4)-P1 (1,2-dioctanoyl) is a synthetic analog of natural phosphatidylinositol (PtdIns) featuring C8:0 fatty acids at the sn-1 and sn-2 positions. The compound contains the same inositol and diacylglycerol (DAG) stereochemistry as the natural compound. PtdIns-(4)-P1 can be phosphorylated to di- (PtdIns-P2; PIP2) and triphosphates (PtdIns-P3; PIP3). Hydrolysis of PtdIns-(4,5)-P2 by phosphoinositide (PI)-specific phospholipase C generates inositol triphosphate (IP3) and DAG which are key second messengers in an intricate biochemical signal transduction cascade.
    • 待估
    35日内发货
    规格
    数量
  • 187-1, N-WASP inhibitor TFA
    T75777
    187-1, N-WASP inhibitor TFA,一种14-aa 环肽及N-WASP 抑制剂,能有效阻止由磷脂酰肌醇 4,5-二磷酸酯 (PIP2) 触发的肌动蛋白装配,IC50 值达 2 μM。该化合物通过维持蛋白质自身的抑制状态,进而抑制N-WASP 激活Arp2 3 复合体。
    • 待询
    规格
    数量
  • BA6b9
    T88799609335-29-7
    BA6b9 是SK4 通道变构抑制剂,针对 CaM-PIP2 结合结构域。该化合物通过与 S4-S5 连接处的 Arg191 和 His192 两个关键残基互作,达到抑制 SK4 通道的效果,其 IC50 值为 8.6 μM (WT SK4)。此外,BA6b9 能显著延长大鼠分离心脏的心房和房室有效不应期(ERP),减少心房颤动(AF)的发生,显示出其在心律失常研究中的应用潜力。
    • ¥ 10600
    2-4周
    规格
    数量
  • PBP10
    PBP 10
    TP1948794466-43-6
    Selective formyl peptide receptor 2 (FPR2) antagonist; cell permeable. Selectively inhibits FPR2-mediated NADPH oxidase activity but has no effect on FPR1 signaling in neutrophils. Displays PIP2 binding activity in vitro and blocks cell motility. Also exh
    • ¥ 2340
    待询
    规格
    数量
  • PBP 10 acetate(794466-43-6 Free base)
    TP1948L
    PBP 10 acetate(794466-43-6 Free base) 是一种选择性甲酰肽受体 2 (FPR2) 拮抗剂。 PBP 10 acetate 选择性抑制 FPR2 介导的 NADPH 氧化酶活性,但对中性粒细胞中的 FPR1 信号传导没有影响。 PBP 10 acetate 在体外表现出 PIP2 结合活性并阻断细胞运动。 PBP 10 acetate 通过抑制病毒诱导的 ERK 激活而表现出针对流感病毒的抗病毒活性。
    询价
  • 187-1, N-WASP inhibitor
    TP1977380488-27-7
    Inhibits neural Wiskott-Aldrich syndrome protein (N-WASP) by stabilizing the autoinhibited state of the protein. Blocks phosphatidylinositol 4,5-bisphosphate (PIP2)-stimulated actin assembly (IC50 ~ 2 μM) but does not directly inhibit actin polymerization
    • ¥ 6048
    待询
    规格
    数量
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